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Enzyme\u2010linked immunosorbent assay and the lymphocyte transformation assay were used to determine immunity. Antibody to antigen S was present significantly more frequently in children with JRA\u2010uveitis than in children with JRA alone, children with nonrheumatic disorders, or controls. These latter groups did not differ in positivity for this antibody. Lymphocyte transformation occurred more frequently in children with JRA\u2013uveitis than in children with JRA alone or controls. Children with JRA alone and controls had similar frequencies of lymphocyte transformation positivity. Enzyme\u2010linked immunosorbent assay positivity and lymphocyte transformation positivity tended to occur in different children. Children with JRA\u2013uveitis who had HLA\u2013B35 had the highest frequency of antibody to antigen S. Immunity to antigen S may be the result of ocular damage by mechanisms other than a pathogenic mechanism per se.<\/jats:p>","DOI":"10.1002\/art.1780300307","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:40:02Z","timestamp":1171489202000},"page":"287-293","source":"Crossref","is-referenced-by-count":23,"title":["Immunity to soluble retinal antigen in patients with uveitis accompanying juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"30","author":[{"given":"R. E.","family":"Petty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W. C.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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