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Fifty\u2010three percent of dogs with joint disease showed significant levels of anti\u2013type I collagen antibodies in their sera, and 56% had anti\u2013type II reactivity. Ninety\u2010one percent of the dogs with joint disease exhibited antibody reactivity to type I collagen in their synovial fluid, and 88% showed reactivity to type II collagen. Correlation of these results with the clinical data indicated that the antibodies had been elicited by antigens derived from cruciate ligaments (type I collagen) and from altered joint cartilage (type II collagen). Immunologic reactivity in this form of canine osteoarthritis is a new concept, and it should be considered in our attempts to understand the pathogenesis of this disease.<\/jats:p>","DOI":"10.1002\/art.1780300311","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:40:02Z","timestamp":1171489202000},"page":"319-327","source":"Crossref","is-referenced-by-count":56,"title":["Antibodies to canine collagen types i and II in dogs with spontaneous cruciate ligament rupture and osteoarthritis"],"prefix":"10.1002","volume":"30","author":[{"given":"Gert W.","family":"Niebauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza I.","family":"Bashey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles 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