{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:08:41Z","timestamp":1760645321840},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6848,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1987,3]]},"abstract":"Abstract<\/jats:title>Using a direct, plaque\u2010forming cell (PFC) assay with sensitized sheep erythrocytes, lymphocytes that secrete IgM rheumatoid factors (RF) have been detected in the peripheral blood of patients with juvenile rheumatoid arthritis. Of 15 juvenile rheumatoid arthritis patients tested, 8 were seropositive and 7 were seronegative, but 6 of the seronegative patients had hidden 19S IgM\u2010RF. Ten patients (5 seropositive and 5 with hidden 19S IgM\u2010RF) demonstrated RF\u2010PFC in their peripheral blood (range 15 to >200 RF\u2010PFC\/106<\/jats:sup> mononuclear cells). Of 11 patients who had active disease, 10 had RF\u2010PFC, and the 4 patients who had inactive disease had no PFC in their peripheral blood. HLA typing of all 15 patients revealed no correlation between the presence of RF\u2010PFC and HLA type.<\/jats:p>","DOI":"10.1002\/art.1780300313","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:40:02Z","timestamp":1171489202000},"page":"335-338","source":"Crossref","is-referenced-by-count":11,"title":["IgM rheumatoid factor plaque\u2010forming cells in juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"30","author":[{"given":"Terry L.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"El\u2010Najdawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Dorner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_1_3_2","first-page":"25","article-title":"Immunological studies in juvenile arthritis","volume":"32","author":"Moore TL","year":"1982","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01857093"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108546"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(84)90013-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198010000-00010"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241008"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210713"},{"key":"e_1_2_1_10_2","first-page":"829","article-title":"19S IgM rheumatoid factor plaque\u2010forming cells in a five year\u2010old patient with juvenile rheumatoid arthritis","volume":"13","author":"Moore TL","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_11_2","first-page":"888","article-title":"The latex fixation test","volume":"21","author":"Singer JM","year":"1956","journal-title":"I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med"},{"key":"e_1_2_1_12_2","first-page":"187","article-title":"HLA antigens in black and white patients with juvenile arthritis: association with rheumatoid factor, hidden rheumatoid factor, antinuclear antibodies, and immune complex levels","volume":"11","author":"Moore TL","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","first-page":"955","volume-title":"Ninth International Workshop on Histocompatibility Testing, 1984","author":"Baur MP","year":"1984"},{"key":"e_1_2_1_14_2","first-page":"437","article-title":"Comparative specificities of serum and synovial cell 19S IgM rheumatoid factors in rheumatoid arthritis","volume":"12","author":"Robbins DL","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_15_2","first-page":"197","article-title":"Rheumatoid factor plaque\u2010forming cells in rheumatoid synovial tissue","volume":"28","author":"Taylor\u2010Ups\u00e4hl MM","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541503"},{"key":"e_1_2_1_17_2","first-page":"247","article-title":"Precipitation of 19S IgM rheumatoid factor\u2010IgG circulating immune complexes in patients with juvenile arthritis by polyethylene glycol and separation by immobilized protein A","volume":"56","author":"Moore TL","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198610000-00017"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780300313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780300313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T08:41:46Z","timestamp":1700728906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780300313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3]]}},"alternative-id":["10.1002\/art.1780300313"],"URL":"https:\/\/doi.org\/10.1002\/art.1780300313","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}