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All fluids contained proteoglycan that was mainly included on Sepharose CL\u20104B; this result indicates cleavage of proteoglycan (which is normally excluded). The hyaluronic acid\u2010binding region was the smallest and most commonly detected fragment. It was relatively free of keratan sulfate and core protein, and it could sometimes bind to hyaluronic acid. Other larger fragments containing core protein and\/or keratan sulfate were detected in every fluid.<\/jats:p>","DOI":"10.1002\/art.1780300506","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:05:20Z","timestamp":1171490720000},"page":"519-529","source":"Crossref","is-referenced-by-count":80,"title":["The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluids of patients with arthritis"],"prefix":"10.1002","volume":"30","author":[{"given":"James","family":"Witter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Roughley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Keystone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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