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Physical activity correlated significantly with BMD in patients with RA, and was found, by multiple regression analysis, to be a significant predictor of femoral bone density in female patients. Multiparity exerted a protective effect on lumbar bone density. Prednisolone (mean dosage 8 mg\/day) was not associated with significantly increased bone loss in women, whereas higher dosages in men (mean 10.3 mg\/day) were associated with increased lumbar bone loss. Reduced physical activity leading to a form of disuse osteoporosis appears to be an important factor in axial bone loss in RA.<\/jats:p>","DOI":"10.1002\/art.1780300701","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:02:34Z","timestamp":1171490554000},"page":"721-728","source":"Crossref","is-referenced-by-count":153,"title":["Determinants of axial bone loss in rheumatoid arthritis"],"prefix":"10.1002","volume":"30","author":[{"given":"Philip N.","family":"Sambrook","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Eisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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