{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:54:28Z","timestamp":1760079268983},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6695,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunocytochemical studies with a monoclonal anti\u2013HLA\u2013DR antibody were performed on skin sections and keratinocyte (KTC) suspensions obtained from suction blisters of active psoriatic plaques. HLA\u2013DR+ KTCs were found in the plaques of 23 of 38 patients with active psoriasis. Of these 23, 16 had clinical findings typical of psoriatic arthritis (PA); none of the 15 patients who lacked HLA\u2013DR+ KTCs had PA. Although KTC HLA\u2013DR expression was more prevalent in patients with severe skin disease, 7 of the 23 patients with HLA\u2013DR + KTCs in active psoriatic plaques had mild skin disease; 4 of these 7 had PA. Nail pitting or duration of skin disease did not account for increased incidence of PA in patients with HLA\u2013DR+ KTCs. All psoriasis patients with arthritis received nonsteroidal antiinflammatory drug therapy; 14 received additional therapy directed primarily to the cutaneous manifestations of psoriasis. Nine of these noted arthritis improvement with concurrent skin response; however, in 5 patients, arthritis activity increased, despite improvement of the cutaneous disease. Two other patients, treated with methotrexate, also had concurrent skin and joint improvement. These data suggest that psoriasis patients with HLA\u2013DR + KTCs are at increased risk for the development of associated arthritis.<\/jats:p>","DOI":"10.1002\/art.1780300809","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:02:16Z","timestamp":1171490536000},"page":"901-907","source":"Crossref","is-referenced-by-count":10,"title":["Marked increase in the frequency of psoriatic arthritis in psoriasis patients with hla\u2013dr+ keratinocytes"],"prefix":"10.1002","volume":"30","author":[{"given":"Alice B.","family":"Gottlieb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu Man","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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