{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:28:56Z","timestamp":1774128536014,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Proteoglycan concentrations in knee joint synovial fluid and in serum from patients with various inflammatory arthritides were studied using an enzymelinked immunosorbent assay. Patients with reactive arthritis, calcium pyrophosphate arthropathy, and juvenile rheumatoid arthritis (age &lt; 20 years) had the highest synovial fluid concentrations. These values differed significantly (<jats:italic>P<\/jats:italic> &lt; 0.001) from those in patients with rheumatoid arthritis, psoriatic arthropathy, and chronic HLA\u2013B27\u2013associated arthropathy. Rheumatoid arthritis patients receiving low\u2010dose prednisolone treatment had higher synovial fluid (<jats:italic>P<\/jats:italic> = 0.006) and serum (<jats:italic>P<\/jats:italic> &lt; 0.001) proteoglycan concentrations than did those taking nonsteroidal antiinflammatory drugs or slowacting antirheumatic drugs. Serum proteoglycan concentrations were near the detection limits, and did not correlate with levels found in paired samples of knee joint synovial fluid. Patients with calcium pyrophosphate arthropathy had the highest mean serum level of proteoglycan. This assay of proteoglycan antigens is a useful tool in the study of proteoglycan metabolism in patients with joint disease. With its use, differences between disease groups and effects of theapy can be distinguished.<\/jats:p>","DOI":"10.1002\/art.1780300903","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:01:43Z","timestamp":1171490503000},"page":"972-979","source":"Crossref","is-referenced-by-count":51,"title":["Cartilage proteoglycans in synovial fluid and serum in patients with inflammatory joint disease. relation to systemic treatment"],"prefix":"10.1002","volume":"30","author":[{"given":"Tore","family":"Saxne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick Heineg","family":"\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank A.","family":"Wollheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"159","volume-title":"Scientific Basis of Rheumatology","author":"Saklatvala J","year":"1982"},{"key":"e_1_2_1_3_2","first-page":"277","volume-title":"Extracellular Matrix Biochemistry","author":"Heineg\u00e5rd D","year":"1984"},{"key":"e_1_2_1_4_2","first-page":"313","volume-title":"Articular cartilage, The Scientific Basis of Orthopaedics","author":"Edward CG","year":"1979"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0307-742X(21)00334-9","article-title":"Trans\u2010synovial exchange of large and small molecules","volume":"7","author":"Simkin PA","year":"1981","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747709095445"},{"key":"e_1_2_1_7_2","first-page":"579","article-title":"Relevance of urinary excretion of alcian blue glycosaminoglycan complexes and hydroxyproline to disease activity in rheumatoid arthritis","volume":"9","author":"Mbuyi JM","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.2.162"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(72)90033-2"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1042\/bst0120874","article-title":"A comparison of glycosaminoglycan content of human synovial fluid in different disease states","volume":"12","author":"Malik SC","year":"1984","journal-title":"Biochem Soc Trans"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281209"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.6.491"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.18.1.49"},{"key":"e_1_2_1_14_2","first-page":"341","volume-title":"Infection and Immunology in the Rheumatic Diseases","author":"Aho K","year":"1976"},{"key":"e_1_2_1_15_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum (suppl)"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418517701800415"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209102748"},{"key":"e_1_2_1_18_2","first-page":"393","article-title":"Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis","volume":"37","author":"Ritchie DM","year":"1968","journal-title":"Q J Med"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90229-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2120659"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300506"},{"key":"e_1_2_1_22_2","unstructured":"LohmanderLS WingstrandH Heineg\u00e5rdD: Transient synovitis of the hip in the child: increased levels of proteoglycan fragments in joint fluid.J Orthop Res(in press)"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032316"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2290063"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02004711"},{"key":"e_1_2_1_26_2","first-page":"141","article-title":"The measurement of cartilage breakdown products in erosive arthropathies (abstract)","volume":"23","author":"Pritchard MH","year":"1984","journal-title":"Br J Rheumatol"}],"container-title":["Arthritis &amp; 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