{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:34:44Z","timestamp":1791354884912,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":6648,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied 10 patients who had arthritis of the knee joint, but no other signs of rheumatic disease. The clinical diagnosis of osteoarthritis was corroborated by arthroscopic evidence of characteristic cartilage degeneration. Signs of inflammation were confined to areas of the synovial membrane that lay near the cartilage; thus, the major part of the joint cavity was not affected. The intensity of the synovial inflammation varied within the areas involved, but was always most pronounced in regions rimming the cartilage. Biopsy samples selected from regions of intensely inflamed synovium contained foci of T lymphocytes, which were bordered by immunoglobulin\u2010carrying B lymphocytes and plasma cells, as well as strongly HLA\u2010DR positive dendritic\u2010like cells adjoined to \u03b1Leu \u2212 3a + T helper lymphocytes. In tissue samples taken from macroscopically noninflamed areas, only a few infiltrating lymphocytes were seen. Thus, the inflammatory synovial changes found in osteoarthritis appear to be anatomically restricted and of varied intensity but, when present, are microscopically indistinguishable from the changes that have been previously described as indicative of rheumatoid arthritis.<\/jats:p>","DOI":"10.1002\/art.1780301001","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:45:12Z","timestamp":1171489512000},"page":"1081-1088","source":"Crossref","is-referenced-by-count":137,"title":["Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis"],"prefix":"10.1002","volume":"30","author":[{"given":"Staffan","family":"Lindblad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hedfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"180","article-title":"An approach to developing criteria for the clinical diagnosis and classification of osteoarthritis: a status report of the American Rheumatism Association Diagnostic Subcommittee on Osteoarthritis","volume":"10","author":"Altman RD","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290816"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_1_5_2","first-page":"108","article-title":"Pain in osteoarthritis","volume":"10","author":"Kellgren JH","year":"1983","journal-title":"J Rheumatol (suppl)"},{"key":"e_1_2_1_6_2","first-page":"189","volume-title":"Degenerative Joints: Test Tubes, Tissues, Models, Man","author":"Verweij A","year":"1982"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197412122912406"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197412192912507"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(81)90012-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/23.3.161"},{"key":"e_1_2_1_11_2","first-page":"249","article-title":"Microscopic comparison of the synovial changes in rheumatoid arthritis and osteoarthritis","volume":"35","author":"Soren A","year":"1976","journal-title":"Z Rheumatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197805000-00004"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68382-4_2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6363.418"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780090302"},{"key":"e_1_2_1_16_2","first-page":"1","article-title":"Osteoarthritis: an arthritis?","volume":"41","author":"Soren A","year":"1982","journal-title":"Z Rheumatol"},{"key":"e_1_2_1_17_2","first-page":"204","article-title":"Inflammatory synovitis in degenerative joint disease","volume":"9","author":"Goldenberg DL","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280904"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00676.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711360304"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1981.tb00198.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91107-7"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00729.x"},{"key":"e_1_2_1_24_2","first-page":"359","article-title":"In situ localization of lymphocyte subsets in synovial membranes of patients with rheumatoid arthritis with monoclonal antibodies","volume":"9","author":"Meijer CLM","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.11.3632"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541597"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.4.1191"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290504"},{"key":"e_1_2_1_29_2","unstructured":"LindbladS HedforsE: The synovial membrane healthy individuals: immunohistochemical overlap with synovitis.Clin Exp Immunol(in press)"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261104"}],"container-title":["Arthritis &amp; 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