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When compared with HLA findings in 243 healthy controls, HLA\u2010DR4 was increased in patients with GCA and PMR, but not in patients with GCA alone. Pooled analysis of data from 4 published papers confirmed the association of DR4 with GCA and PMR (<jats:italic>P<\/jats:italic> \/0.00001). Patients with PMR but negative findings of temporal artery biopsies also showed an increased frequency of HLA\u2010DR4, but this did not reach statistical significance, probably because of the small number of subjects. It is likely that the increased frequency of DR4 in GCA patients is related to its association with PMR.<\/jats:p>","DOI":"10.1002\/art.1780301113","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:45:00Z","timestamp":1171489500000},"page":"1293-1297","source":"Crossref","is-referenced-by-count":51,"title":["Hla\u2010dr4 in giant cell arteritis: association with polymyalgia rheumatica syndrome"],"prefix":"10.1002","volume":"30","author":[{"given":"Joan E.","family":"Richardson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna D.","family":"Gladman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Fam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.","family":"Keystone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197101000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-2-162"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-1-19"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.3.238"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261005"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170105"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748009098156"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.141.1.115"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261007"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197503132921121"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6093.989"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197610142951623"},{"key":"e_1_2_1_14_2","first-page":"321","article-title":"HLA antigens in patients with giant cell arteritis and polymyalgia rheumatica","volume":"4","author":"Hunder GG","year":"1977","journal-title":"J Rheumatol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6118.989-b"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230417"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107093050216"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1984.tb00399.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(85)90011-4"},{"key":"e_1_2_1_20_2","first-page":"993","article-title":"HLA\u2010DR locus antigens in polymyalgia rheumatica and giant cell arteritis","volume":"8","author":"Calamia KT","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_21_2","first-page":"659","article-title":"Histocompatibility antigens in polymyalgia rheumatica and giant cell arteritis","volume":"10","author":"Armstrong RD","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260717"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240614"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-8545-5_3"},{"key":"e_1_2_1_25_2","first-page":"109","volume-title":"Statistical Methods for Rates and Proportions","author":"Fleiss JL","year":"1973"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(83)90025-2"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198412133112402"},{"key":"e_1_2_1_28_2","first-page":"274","article-title":"HLA and disease manifestations in rheumatoid arthritis: a Canadian experience","volume":"13","author":"Gladman DD","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.6.3877"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(84)90012-X"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69770-8_118"}],"container-title":["Arthritis &amp; 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