{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:41:11Z","timestamp":1761100871998},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6542,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some patients with chronically elevated large granular lymphocyte (LGL) numbers have rheumatoid arthritis (RA). Since these patients also may have neutropenia and splenomegaly, their symptoms resemble those of patients diagnosed as having Felty's syndrome (FS). We studied the immunophenotypic and genotypic characteristics of mononuclear cells from patients with RA and neutropenia to better determine the extent of heterogeneity in this condition. Four patients had markedly increased numbers of LGLs, which expressed HNK\u20101 antigen and IgG Fc receptors. In contrast, the remaining 8 patients, who had FS, had normal LGL counts, and surface marker studies showed normal numbers of HNK\u20101 and IgG Fc receptor positive cells. Clonal rearrangement of the T cell receptor \u03b2 chain gene was demonstrated in all 4 patients with excess LGLs, whereas a germline configuration of this gene was present in all 6 FS patients in whom this was studied. These results suggest that there are diverse groups among patients with RA and neutropenia. Since prognosis may differ, it is important to recognize that some patients who are considered to have Felty's syndrome may have a clonal proliferation of LGLs.<\/jats:p>","DOI":"10.1002\/art.1780310105","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:57:07Z","timestamp":1171490227000},"page":"31-36","source":"Crossref","is-referenced-by-count":47,"title":["Clonal proliferation of large granular lymphocytes in rheumatoid arthritis"],"prefix":"10.1002","volume":"31","author":[{"suffix":"Jr","given":"Thomas P.","family":"Loughran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Starkebaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Kidd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Neiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1182\/blood.V64.6.1146.1146","article-title":"T gamma\u2010lymphoproliferative disorders in man and experimental animals: a review of the clinical, cellular, and functional characteristics","volume":"64","author":"Reynolds CW","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.146.6.1201"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109556"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood.V66.2.259.259","article-title":"Granulated T cell lymphocytosis with neutropenia: malignant or benign chronic lymphoproliferative disorder?","volume":"66","author":"McKenna RW","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_6_2","first-page":"16","article-title":"Chronic arthritis in the adult, associated with splenomegaly and leukopenia: a report of five cases of an unusual clinical syndrome","volume":"35","author":"Felty AR","year":"1924","journal-title":"Johns Hopkins Hosp Bull"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-3-357"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1182\/blood.V69.1.72.72","article-title":"Induction of NK activity in large granular lymphocyte leukemia: activation with anti\u2010CD3 monoclonal antibody and interleukin 2","volume":"69","author":"Loughran TP","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_9_2","first-page":"325","volume-title":"Differential expression of pan T\u2010cell antigens on human T\u2010cell subsets, Perspectives in Immunogenetics and Histocompatibility","author":"Ledbetter JA","year":"1985"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(84)90002-1"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.127.3.1024"},{"key":"e_1_2_1_12_2","volume-title":"Molecular Cloning: A Laboratory Manual. 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