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This method generates HLA\u2010DR\u2010DQ haplotypes that are highly correlated with HLA\u2010DR serology. Thirty\u2010five of the 43 RA patients (81%) were positive for one or for both of the DR4\u2010associated DR\u2010DQ haplotypes, 4.1 and 4.2. Among these patients, the 4.1 haplotype was found significantly more often than in DR4 + controls (<jats:italic>P<\/jats:italic> &lt; 0.01). The haplotype segment C3;B15;DR4 was present in all RA patients in 4 of the 5 families, and included the DR\u2010DQ4.1 haplotype.<\/jats:p>","DOI":"10.1002\/art.1780310111","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T21:57:07Z","timestamp":1171490227000},"page":"72-79","source":"Crossref","is-referenced-by-count":24,"title":["A dr4\u2010associated dr\u2010dq haplotype is significantly associated with rheumatoid 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