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Most of these patients recovered uneventfully, with or without the discontinuation of cyclophosphamide, but 4 patients suffered a significant loss of blood, and bladder carcinoma developed in 3. New microhematuria also occurred in 52 patients (47%). The dose and duration of cyclophosphamide were greater in the group that had urotoxicity. Long\u2010term followup of patients with hemorrhagic cystitis is mandatory for the detection of late recurrences or the development of bladder malignancy. New therapies are being directed at protecting the bladder from urotoxicity during cyclophosphamide treatment.<\/jats:p>","DOI":"10.1002\/art.1780310402","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:13:04Z","timestamp":1171491184000},"page":"465-470","source":"Crossref","is-referenced-by-count":81,"title":["Cyclophosphamide\u2010induced bladder toxicity in wegener's granulomatosis"],"prefix":"10.1002","volume":"31","author":[{"given":"Thomas J.","family":"Stillwell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Ralph C.","family":"Benson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Deremee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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