{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:57:01Z","timestamp":1770699421834,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6451,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence and clinical correlations of antithreonyl\u2013transfer RNA synthetase (anti\u2013PL\u20107), as well as the relationship of anti\u2013PL\u20107 to anti\u2013histidyl\u2013transfer RNA synthetase (anti\u2013Jo\u20101) were studied in 109 sera from patients with myositis. Inhibition of threonine aminoacylation was used to screen for anti\u2013PL\u20107. Sera from 3 patients, 2 with polymyositis and 1 with polymyositis\u2013overlap syndrome, and a fourth serum from a patient with dermatomyositis, which was previously found to contain anti\u2013PL\u20107, inhibited &gt;90% of activity (3.7% of 109 sera). All 4 sera reacted strongly in an enzyme\u2010linked immunosorbent assay with enzyme that was either affinity purified with anti\u2013PL\u20107 or was biochemically purified. There was no indication of cross\u2010reactivity by aminoacylation inhibition or, for most sera, by enzyme\u2010linked immunosorbent assay. Anti\u2013PL\u20107 is an uncommon myositis\u2010associated antibody that is independent of anti\u2013Jo\u20101, but is directed at a functionally related enzyme.<\/jats:p>","DOI":"10.1002\/art.1780310408","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:13:04Z","timestamp":1171491184000},"page":"515-524","source":"Crossref","is-referenced-by-count":57,"title":["Antibody to threonyl\u2013transfer rna synthetase in myositis sera"],"prefix":"10.1002","volume":"31","author":[{"given":"Ira N.","family":"Targoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank C.","family":"Arnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Reichlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271011"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230802"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00915286"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280711"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.420"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.4049\/jimmunol.138.9.2874","article-title":"Measurement of antibody to Jo\u20101 by ELISA and comparison to enzyme inhibitory activity","volume":"138","author":"Targoff IN","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/304177a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1984.tb08022.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.5.1281"},{"key":"e_1_2_1_11_2","first-page":"105","article-title":"Cellular protein and RNA antigens in autoimmune disease","volume":"2","author":"Bernstein RM","year":"1984","journal-title":"Mol Biol Med"},{"key":"e_1_2_1_12_2","first-page":"189","volume-title":"Autoantibodies to Jo\u20101 and other tRNA\u2010related antigens in myositis, Rheumatology\u201385","author":"Mathews MB","year":"1985"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1982.tb03042.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_16_2","first-page":"286","volume-title":"Precipitating antibodies in progressive systemic sclerosis: specificity and clinical associations, Current Topics in Rheumatology: Systemic Sclerosis (Scleroderma)","author":"Reichlin M","year":"1981"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260505"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(87)90308-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6438.151"},{"key":"e_1_2_1_20_2","first-page":"663","article-title":"Antibody to Jo\u20101 in polymyositis\/dermatomyositis: association with interstitial pulmonary disease","volume":"11","author":"Hochberg MC","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90677-6"},{"key":"e_1_2_1_22_2","first-page":"273","volume-title":"Jo\u20101 and other myositis autoantibodies, Rheumatology\u201485","author":"Bernstein RM","year":"1985"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00563a007"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1016\/S0021-9258(17)47285-1","article-title":"Chinese hamster ovary cells resistant to borrelidin overproduce threonyl\u2010tRNA synthetase","volume":"259","author":"Gerken SC","year":"1984","journal-title":"J Biol Chem"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90740-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)60598-X"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/249032a0"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-34-1-177"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92429-3"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01539923"}],"container-title":["Arthritis &amp; 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