{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:03:25Z","timestamp":1790834605025,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6421,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this investigation of B cells expressing the CD5 (Leu\u20101) cell surface marker, we found increased numbers of these cells in 13 of 19 patients with primary Sj\u00f6gren's syndrome (SS) (68%), as well as in the rheumatoid arthritis patients. The percentage of B cells that demonstrated increased expression of CD5 was 46% in SS patients, 47% in rheumatoid arthritis patients, 24% in systemic lupus erythematosus patients, and 26% in normal subjects. Over a 2\u2010year period, CD5 expression on B cells was a stable finding in several patients, except for 2 who required either steroid therapy or combined chemotherapy and irradiation for malignant lymphoma. Both of these patients had clinical remissions and their levels of CD5+ B cells returned to normal. The first patient had a clinical picture of SS\/systemic lupus erythematosus overlap, associated with polyclonal B cell activation and decreased production of interleukin\u20102 in response to stimulation with phytohemagglutinin. These cellular immune abnormalities returned to normal after the institution of corticosteroids. Our observations suggest a relationship between the CD5+ B cell abnormality and disease activity. The results are discussed in relation to immunoregulatory properties of CD5+ B cells in autoimmune mice and the characteristic predisposition to malignant lymphoma among SS patients.<\/jats:p>","DOI":"10.1002\/art.1780310509","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:10:09Z","timestamp":1171491009000},"page":"642-647","source":"Crossref","is-referenced-by-count":181,"title":["B cells expressing cd5 are increased in sj\u00f6gren's syndrome"],"prefix":"10.1002","volume":"31","author":[{"given":"Michael","family":"Dauphin\u00e9e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zair","family":"Tovar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Talal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-50118-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106221"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(64)90101-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110984"},{"key":"e_1_2_1_6_2","volume-title":"The biological significance of lymphoproliferation in Sj\u00f6gren's syndrome, Rheumatology","author":"Talal N","year":"1985"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500123"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198704303161803"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3458307"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.4049\/jimmunol.130.6.2663","article-title":"High incidence of free monoclonal \u03bb light chains in the sera of patients with Sj\u00f6gren's syndrome","volume":"130","author":"Moutsopoulos HM","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.2.109"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260803"},{"key":"e_1_2_1_13_2","volume-title":"Interferon and natural killer cells in rheumatic diseases, Immunology of Rheumatic Diseases","author":"Talal N","year":"1985"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.2.477"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.05.040187.000545"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.8.2494"},{"key":"e_1_2_1_17_2","unstructured":"StallAM FarinasMC TarlintonDM LalorPA HerzenbergLA StroberS HerzenbergLA: Ly\u20101 B cell clones similar to human chronic lymphocytic leukemia (B\u2010CLL) routinely develop in older normal mice and young autoimmune (NZB\u2010related) animals. Submitted for publication"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170612"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.4049\/jimmunol.138.7.2057","article-title":"Idiotype\u2010specific Ly\u20101 B cell\u2010mediated helper activity: hybridomas that produce anti\u2010idiotype antibody and nonimmunoglobulin lymphokine(s)","volume":"138","author":"Sherr DH","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280903"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3105056"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3105057"},{"key":"e_1_2_1_23_2","unstructured":"Dauphin\u00e9eMJ KincaidW TalalN:Increased incidence of B\u2010cells coexpressing a T cell marker in rheumatoid arthritis Sixth International Congress of Immunology. 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