{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:47:49Z","timestamp":1790750869348,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6421,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HLA class II antigens were determined in 65 patients with biopsy\u2010proven giant cell arteritis (GCA). An increase in DR4 antigen frequency was found in the patients (40%) compared with that in 200 healthy controls (20%) (<jats:italic>P<\/jats:italic>corr &lt; 0.05). DR4 was significantly more frequent in GCA patients with polymyalgia rheumatica (PMR) than in those without PMR (58.8% versus 19.3%) (<jats:italic>P<\/jats:italic> &lt; 0.005). HLA\u2013DR4 frequency in GCA patients without PMR was similar to that in the control population (20%). Patients with severe, disabling PMR had DR4 more frequently (90%) than did those with moderate symptoms who required medical care because of cranial arteritis manifestations (41.6%) (<jats:italic>P<\/jats:italic> &lt; 0.05). We conclude that, in GCA patients, association with DR4 is mainly related to the manifestation of the disease as PMR. We discuss clinical and immunogenetic similarities between PMR and other DR4\u2010associated rheumatic disorders. Common immunopathogenic mechanisms leading to clinical overlap among them are suggested.<\/jats:p>","DOI":"10.1002\/art.1780310515","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:10:09Z","timestamp":1171491009000},"page":"678-682","source":"Crossref","is-referenced-by-count":61,"title":["Polymyalgia rheumatica: a syndrome associated with hla\u2013dr4 antigen"],"prefix":"10.1002","volume":"31","author":[{"given":"Maria\u2010Cinta","family":"Cid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Ercilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Vilaseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimon","family":"Sanmarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Villalta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Ingelmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Urbano\u2010Marquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197101000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90744-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-2-162"},{"key":"e_1_2_1_5_2","first-page":"1","article-title":"Giant\u2010cell arteritis","volume":"658","author":"Bengtsson BA","year":"1982","journal-title":"Acta Med Scand"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250124"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90309-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-672"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780170105"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0307-742X(21)00600-7","article-title":"Giant\u2010cell arteritis and polymyalgia rheumatica","volume":"11","author":"Hunder GG","year":"1985","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197503132921121"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197610142951623"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6093.989"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1977.tb01084.x"},{"key":"e_1_2_1_15_2","first-page":"321","article-title":"HLA antigens in patients with giant\u2010cell arteritis and polymyalgia rheumatica","volume":"4","author":"Hunder GG","year":"1977","journal-title":"J Rheumatol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6118.989-b"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230417"},{"key":"e_1_2_1_18_2","first-page":"659","article-title":"Histocompatibility antigens in polymyalgia rheumatica and giant\u2010cell (temporal) arteritis","volume":"10","author":"Armstrong RD","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(85)90011-4"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1984.tb00399.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271218"},{"key":"e_1_2_1_22_2","first-page":"993","article-title":"HLA\u2010DR locus antigens in polymyalgia rheumatica and giant cell arteritis","volume":"8","author":"Calamia KT","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260717"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198106000-00001"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(83)90057-5"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/204998b0"},{"key":"e_1_2_1_27_2","volume-title":"B\u2010lymphocyte isolation by thrombin\u2010nylon wool, Histocompatibility Testing 1980","author":"Danilovs JA","year":"1980"},{"key":"e_1_2_1_28_2","volume-title":"Histocompatibility Testing 1984","author":"Mayr WR","year":"1984"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0307-742X(21)00626-3"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-3-387"},{"key":"e_1_2_1_32_2","volume-title":"Rheumatoid arthritis, Histocompatibility Testing 1984","author":"Christiansen FT","year":"1984"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(84)90012-X"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/24.1.27"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261201"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.4.379"},{"key":"e_1_2_1_37_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270104"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-1-61"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.7.534"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281208"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.146.2.289"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198503000-00002"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780310515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780310515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T08:36:24Z","timestamp":1700728584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780310515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["10.1002\/art.1780310515"],"URL":"https:\/\/doi.org\/10.1002\/art.1780310515","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}