{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:34:05Z","timestamp":1788582845737,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6390,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We prospectively studied 91 infants born to women with systemic lupus erythematosus (SLE) or with SLE\u2010like disease. Thirty\u2010eight infants, including 3 sets of twins, were born to women who had anti\u2010Ro, anti\u2010La, or anti\u2010RNP antibodies. Four infants had definite neonatal lupus, and 4 had possible neonatal lupus. No prospectively studied infant had congenital heart block. The presence of neonatal lupus did not correlate with the titer of anti\u2010Ro antibodies. During the same time period, 2 additional babies with neonatal lupus and congenital heart block were born to mothers not previously known to have SLE. Taken together, these findings confirm the association of anti\u2010Ro antibody with neonatal lupus, but indicate that life\u2010threatening neonatal lupus is rare in children born to mothers who are known to have SLE, even when antibodies to Ro, La, or RNP are present. Prophylactic therapy is therefore not indicated for these women. An important proportion of mothers bearing children with neonatal lupus do not have recognized SLE and, currently, cannot be prospectively identified.<\/jats:p>","DOI":"10.1002\/art.1780310601","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:10:09Z","timestamp":1171491009000},"page":"697-701","source":"Crossref","is-referenced-by-count":133,"title":["Neonatal lupus risk to newborns of mothers with systemic lupus erythematosus"],"prefix":"10.1002","volume":"31","author":[{"given":"Michael D.","family":"Lockshin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa","family":"Bonfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Elkon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice L.","family":"Druzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198411000-00003"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198704303161807"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260215"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-4-518"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291013"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300106"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0307-742X(21)00607-X","article-title":"Lupus pregnancy","volume":"11","author":"Lockshin MD","year":"1985","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_9_2","first-page":"259","article-title":"Antibody to cardiolipin, lupus anticoagulant, and fetal death","volume":"14","author":"Lockshin MD","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198507183130304"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.4049\/jimmunol.134.6.3819","article-title":"Fine specificities of autoantibodies directed against the Ro, La, Sm, RNP, and Jo\u20101 proteins defined by two\u2010dimensional gel electrophoresis and immunoblotting","volume":"134","author":"Elkon KB","year":"1985","journal-title":"J Immunol"},{"issue":"4","key":"e_1_2_1_13_2","first-page":"S","article-title":"Antibody to cardiolipin and to Ro\/La (SSA\/SSB) antigens in maternal\u2010cord serum pairs (abstract)","volume":"29","author":"Qamar T","year":"1986","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280110"},{"key":"e_1_2_1_15_2","first-page":"90","article-title":"Fetal wastage in women with anti\u2010Ro (SSA) antibody","volume":"13","author":"Watson RM","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281202"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280306"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-5-592"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780310601","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780310601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T08:29:34Z","timestamp":1700728174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780310601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,6]]}},"alternative-id":["10.1002\/art.1780310601"],"URL":"https:\/\/doi.org\/10.1002\/art.1780310601","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6]]}}}