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The antibody levels in all pre\u2010illness serum specimens fell within the range seen for the healthy controls. Four RA patients had an IgG class antibody level and 4 had an IgM class antibody level that was above the highest level observed for controls, in at least 1 serum sample. No significant difference in the mean level of anticollagen antibodies was observed in the followup specimens from RA patients.<\/jats:p>","DOI":"10.1002\/art.1780310612","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:10:09Z","timestamp":1171491009000},"page":"776-779","source":"Crossref","is-referenced-by-count":32,"title":["Antibodies against native type ii collagen do not precede the clinical onset of rheumatoid arthritis"],"prefix":"10.1002","volume":"31","author":[{"given":"Timo","family":"M\u00f6tt\u00f6nen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Hannonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martti","family":"Oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Rautiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilmari","family":"Jokinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Arvilommi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Palosuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimmo","family":"Aho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250801"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"Monkeying around with collagen autoimmunity and arthritis","volume":"54","author":"Stuart JM","year":"1986","journal-title":"Lab Invest"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.1.6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260703"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271207"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271101"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90436-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1986.tb02086.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283644"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112903"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280503"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1986.tb02196.x"},{"key":"e_1_2_1_14_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_15_2","first-page":"393","article-title":"Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis","volume":"27","author":"Ritchie DM","year":"1968","journal-title":"Q J Med"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/20.1.14"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418517701800415"},{"key":"e_1_2_1_18_2","first-page":"425","article-title":"Antibodies to native and denatured type II collagen in children with rheumatic diseases","volume":"11","author":"Rosenberg AM","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0260-4639(22)00013-5","article-title":"Autoantibodies in rheumatoid arthritis: some new facts","volume":"1","author":"Holborow EJ","year":"1981","journal-title":"Clin Immunol Allergy"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.8.684"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290204"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000233063"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291103"}],"container-title":["Arthritis &amp; 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