{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:58Z","timestamp":1760188858511},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6390,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the subsets of synovial fluid (SF) lymphocytes and their activation states in 4 subtypes of juvenile rheumatoid arthritis. The expression of lymphocyte differentiation antigens and activation markers (Ia and Tac) appeared to be similar in these subgroups. Tac+ DNA\u2010synthesizing T blasts represented, at most, 5% of all SF mononuclear cells. This finding was in clear contrast to the high proportion of Ia\u2010positive SF mononuclear cells. There were no differences in Ia and Tac expression or DNA synthesis among the different juvenile rheumatoid arthritis subgroups. This finding suggests that the cell\u2010mediated immune response may represent secondary features of the disease that are involved as a final common pathogenetic pathway.<\/jats:p>","DOI":"10.1002\/art.1780310613","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:10:09Z","timestamp":1171491009000},"page":"780-783","source":"Crossref","is-referenced-by-count":11,"title":["Synovial fluid lymphocytes in different subtypes of juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"31","author":[{"given":"Ville","family":"Bergroth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yrj\u00f6 T.","family":"Konttinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirkko","family":"Pelkonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervi","family":"Haapala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarkko","family":"Haapasaari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Kunnamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Friman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"76","article-title":"The seronegative spondylarthropathies of childhood","volume":"143","author":"Schaller JG","year":"1979","journal-title":"Clin Orthop"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_1_4_2","first-page":"1076","article-title":"Routine analysis of synovial fluid cells is of value in the differential diagnosis of arthritis in children","volume":"13","author":"Kunnamo I","year":"1986","journal-title":"J Rheumatol"},{"issue":"2","key":"e_1_2_1_5_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin\u2010biotinperoxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu S\u2010M","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01909.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01896.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200302"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00642.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00643.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290107"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.4049\/jimmunol.133.3.1230","article-title":"Activated T cells in vivo and in vitro: divergence in expression of Tac and Ia antigens in the nonblastoid small T cells of inflammation and normal T cells activated in vitro","volume":"133","author":"Burmester GR","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","first-page":"109","article-title":"Chemotactic response to C3a and C5a. 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Evaluation of C3a and C5a leukotaxis in vitro and under stimulated in vivo conditions","volume":"120","author":"Fernandez HN","year":"1978","journal-title":"J Immunol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/286264a0"},{"key":"e_1_2_1_16_2","first-page":"254","article-title":"Intraarticular T lymphocytes in monoarticular and oligoarticular inflammatory joint diseases","volume":"13","author":"Jahn B","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_17_2","first-page":"599","article-title":"Longitudinal study of the presence of hidden 19S IgM rheumatoid factor in juvenile rheumatoid arthritis","volume":"9","author":"Moore TL","year":"1982","journal-title":"J Rheumatol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780310613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780310613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T08:30:51Z","timestamp":1700728251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780310613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,6]]}},"alternative-id":["10.1002\/art.1780310613"],"URL":"https:\/\/doi.org\/10.1002\/art.1780310613","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6]]}}}