{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:17:33Z","timestamp":1791217053249,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6390,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin\u20106 (IL\u20106), also called 26\u2010kd protein, hybridoma plasmacytoma growth factor, \u03b2<jats:sub>2<\/jats:sub>\u2010interferon, or B cell stimulatory factor 2, is a recently described human cytokine with multiple growth and differentiation activities. Using a very sensitive bioassay based on the growth factor activity of this protein for B cell hybridomas, we found that IL\u20106 activity was significantly elevated in synovial fluid from patients with rheumatoid arthritis (RA) or other inflammatory arthritides, as compared with that in a group of patients with osteoarthritis. Moreover, IL\u20106 was detected in about one\u2010third of the serum samples from patients with RA. In the latter group, we found a significant correlation between serum IL\u20106 activity and serum levels of C\u2010reactive protein, \u03b1<jats:sub>1<\/jats:sub>\u2010acid glycoprotein, \u03b1<jats:sub>1<\/jats:sub>\u2010antitrypsin, fibrinogen, and haptoglobin, which indicates that IL\u20106 is related to disease activity in patients with RA.<\/jats:p>","DOI":"10.1002\/art.1780310614","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:10:09Z","timestamp":1171491009000},"page":"784-788","source":"Crossref","is-referenced-by-count":665,"title":["Interleukin\u20106 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides"],"prefix":"10.1002","volume":"31","author":[{"given":"Fr\u00e9d\u00e9ric A.","family":"Houssiau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Devogelaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Van","family":"Damme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Nagant De","family":"Deuxchaisnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques Van","family":"Snick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260806"},{"key":"e_1_2_1_3_2","first-page":"109","article-title":"The demonstration of an interleukin\u20102 like activity in the synovial fluids of rheumatoid arthritis patients","volume":"10","author":"Wilkins JA","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","first-page":"402","article-title":"Cytokines and the chronic inflammation of rheumatic disease. II. The presence of interleukin\u20102 in synovial fluids","volume":"58","author":"Nouri AME","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1984.tb00474.x"},{"key":"e_1_2_1_6_2","first-page":"316","article-title":"Detection and partial characterization of human B cell colony stimulating activity in synovial fluids of patients with rheumatoid arthritis","volume":"60","author":"Fay AC","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.6.672"},{"issue":"4","key":"e_1_2_1_8_2","first-page":"S83","article-title":"Lymphokines in inflammatory arthritis (abstract)","volume":"30","author":"Mahmood T","year":"1987","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04531.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02357.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.3.914"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/324073a0"},{"key":"e_1_2_1_13_2","first-page":"175","article-title":"A growth factor for B cell hybridomas produced by human monocytes","volume":"10","author":"Aarden L","year":"1985","journal-title":"Lymphokines"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830171004"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170102"},{"key":"e_1_2_1_16_2","unstructured":"HoussiauFA CouliePG OliveD van SnickJ:Synergistic activation of human T cells by interleukin 1 and interleukin 6. Submitted for publication"},{"key":"e_1_2_1_17_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9679"},{"key":"e_1_2_1_20_2","first-page":"320","article-title":"Elevated levels of the 26K human hybridoma growth factor in cerebrospinal fluid of patients with acute infection of the central nervous system","volume":"71","author":"Houssiau FA","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7251"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780310614","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780310614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T08:30:58Z","timestamp":1700728258000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780310614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,6]]}},"alternative-id":["10.1002\/art.1780310614"],"URL":"https:\/\/doi.org\/10.1002\/art.1780310614","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6]]}}}