{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:34Z","timestamp":1760188834419},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6329,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C4A and C4B allotypes were compared in 20 patients with Felty's syndrome (FS), 52 patients with rheumatoid arthritis (RA), and 55 control subjects. Nineteen of the FS patients had HLA\u2013DR4. A C4B\u2010null allele was more frequent in the patients with FS (60%) than in either the RA patients (15%) or the control subjects (26%). Only the differences between patients with FS and those with RA remained statistically significant when DR4 positive subjects were compared. The C4B null allele may identify individuals within the rheumatoid population who are at risk of developing particular systemic complications.<\/jats:p>","DOI":"10.1002\/art.1780310807","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:09:59Z","timestamp":1171490999000},"page":"984-989","source":"Crossref","is-referenced-by-count":13,"title":["Complement c4b\u2013null alleles in felty's syndrome"],"prefix":"10.1002","volume":"31","author":[{"given":"Wendy","family":"Thomson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Grennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Rheumatoid arthritis, Histocompatibility Testing","author":"Stastny P","year":"1980"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.3.279"},{"key":"e_1_2_1_4_2","first-page":"718","article-title":"A comparison of clinical and immunogenetic features in familial and sporadic rheumatoid arthritis","volume":"14","author":"Sanders PA","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231126"},{"key":"e_1_2_1_6_2","first-page":"628","article-title":"HLA\u2013DR4 in Felty's syndrome (letter)","volume":"12","author":"Friman C","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.7.534"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01561689"},{"issue":"2","key":"e_1_2_1_9_2","first-page":"194","article-title":"Comparison of established haplotypes bearing HLA\u2010A, B and DR antigens and C4 and Bf genotypes in 54 multicase rheumatoid families and 24 control families (abstract)","volume":"25","author":"Thomson W","year":"1986","journal-title":"Br J Rheumatol"},{"key":"e_1_2_1_10_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.6.3576"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2390763"},{"key":"e_1_2_1_13_2","first-page":"269","article-title":"Genetic markers in rheumatoid arthritis: relationship to toxicity from D\u2010penicillamine","volume":"13","author":"Stockman A","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90250-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(87)90044-9"},{"key":"e_1_2_1_16_2","volume-title":"Felty's syndrome, Textbook of Rheumatology","author":"Pinals R","year":"1981"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541352"},{"key":"e_1_2_1_18_2","first-page":"292","article-title":"Complement\u2010mediated inhibition of immune precipitation in patients with immune complex disease","volume":"51","author":"Naama JK","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb02052.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03969.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190316"}],"container-title":["Arthritis &amp; 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