{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:53Z","timestamp":1760188853225},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6329,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have developed a model of IgE\u2010dependent, mast cell\u2013mediated arthritis in rats. One knee joint (test joint) of a Sprague\u2010Dawley rat was injected with 1 \u03bcg of a monoclonal IgE specific for dinitrophenol, and the contralateral (control) joint was injected with the same amount of an irrelevant monoclonal IgE in phosphate buffered saline or with phosphate buffered saline alone. Within 5 minutes of intravenous injection of antigen, an acute, transient arthritis occurred in the test joints only, with swelling and extravasation of intravascular blue dye and <jats:sup>125<\/jats:sup>I\u2010labeled albumin, decreased numbers of stainable mast cells, and decreased histamine content of the joint synovium. Pretreatment of experimental animals with H1 and H2 antihistamines did not completely block the reaction. These data show that IgE\u2010dependent synovial mast cell degranulation causes a transient, nondestructive arthritis, reminiscent of lupus arthritis and intermittent hydrarthrosis.<\/jats:p>","DOI":"10.1002\/art.1780310820","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:09:59Z","timestamp":1171490999000},"page":"1063-1067","source":"Crossref","is-referenced-by-count":20,"title":["Demonstration and characterization of a transient arthritis in rats following sensitization of synovial mast cells with antigen\u2010specific ige and parenteral challenge with specific antigen"],"prefix":"10.1002","volume":"31","author":[{"given":"Daniel G.","family":"Malone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean D.","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270803"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290803"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300202"},{"key":"e_1_2_1_5_2","first-page":"321","article-title":"Morphologic demonstration of two stages in the development of type II collagen\u2010induced arthritis","volume":"46","author":"Caulfield JP","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90233-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.1.24"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.1.76"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01987994"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/bj2300083","article-title":"Mast cell products and heparin stimulate the production of mononuclear cell factor by cultured human monocytes\/macrophages","volume":"230","author":"Taylor DJ","year":"1985","journal-title":"Biochem J"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1975.tb00431.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290202"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(73)90077-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290210"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250617"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270801"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780310820","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780310820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T08:20:46Z","timestamp":1700727646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780310820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1988,8]]}},"alternative-id":["10.1002\/art.1780310820"],"URL":"https:\/\/doi.org\/10.1002\/art.1780310820","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,8]]}}}