{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:59:10Z","timestamp":1760266750252},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6298,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new common idiotype, designated PR4, is described. This idiotype was originally identified on a human hybridoma\u2010derived monoclonal antibody from a patient with leprosy, which binds the major <jats:italic>Mycobacterium leprae<\/jats:italic>\u2010derived antigen, phenolic glycolipid\u20101, poly(ADP)\u2010ribose, DNA, and poly(dT). The PR4 idiotype was found in patients with systemic lupus erythematosus (SLE) (70%), rheumatoid arthritis (40%), and Sj\u00f6gren's syndrome (15%). It was not, however, found in the spouses of the SLE patients or (unlike other lupus idiotypes) in their healthy first\u2010degree relatives. Although no correlation between PR4 idiotype levels and disease activity in SLE was found, a subset of rheumatoid arthritis patients with high levels of the idiotype was identified.<\/jats:p>","DOI":"10.1002\/art.1780310903","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T22:19:00Z","timestamp":1171491540000},"page":"1097-1104","source":"Crossref","is-referenced-by-count":21,"title":["Studies of a common idiotype pr4 in autoimmune rheumatic disease"],"prefix":"10.1002","volume":"31","author":[{"given":"W.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zumla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Locniskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Voller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. P. W. J.","family":"Mcadam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Isenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"171","article-title":"Systemic lupus erythematosus: idiotypes and anti\u2010idiotypes","volume":"7","author":"Isenberg DA","year":"1986","journal-title":"Plasma Ther Transfus Technol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830150412"},{"key":"e_1_2_1_4_2","first-page":"393","article-title":"Shared idiotypes are expressed on mouse and human anti\u2010DNA antibodies","volume":"56","author":"Morgan A","year":"1985","journal-title":"Immunology"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112849"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"ZumlaA WilliamsW ShallS LocniskarM LeighI McAdamKPWJ IsenbergDA:Human monoclonal antibodies to phenolic glycolipid\u20101 from leprosy patients cross\u2010react with poly(ADP\u2010ribose) polynucleotides and tissue bound antigens. 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