{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:35Z","timestamp":1791300515109,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":6268,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We characterized serum from a patient with polymyositis, and found that it produced a peripheral (rim) fluorescent antinuclear antibody pattern on rat liver substrate. Indirect immunofluorescence analysis revealed a punctate pattern at the nuclear surface of PtK2, BHK\u201021, and HEp\u20102 cells. This pattern was still present after sequential extraction in situ with non\u2010ionic detergent, DNase, RNase, and high ionic strength buffer (2\n                    <jats:italic>M<\/jats:italic>\n                    NaCl). Immunogold electron microscopic localization was specific for nuclear pore complexes. By immunoblot analysis, the antigens were polypeptides of 200 kd and 130 kd that were enriched in the nuclear fraction.\n                  <\/jats:p>","DOI":"10.1002\/art.1780311017","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:55:49Z","timestamp":1171472149000},"page":"1322-1327","source":"Crossref","is-referenced-by-count":23,"title":["A novel autoantibody causing a peripheral fluorescent antinuclear antibody pattern is specific for nuclear pore complexes"],"prefix":"10.1002","volume":"31","author":[{"given":"Andr\u00e9","family":"Dagenais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Bibor\u2010Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Sen\u00e9cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Autoantibodies to nuclear antigens: screening assays, Autoantibodies to Nuclear Antigens (ANA): Advances in Laboratory Tests and Significance in Systemic Rheumatic Diseases","author":"Nakamura RM","year":"1985"},{"key":"e_1_2_1_3_2","volume-title":"Antinuclear antibodies, Textbook of Rheumatology","author":"Reichlin M","year":"1985"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105669"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.14.4374"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.3.750"},{"key":"e_1_2_1_7_2","first-page":"266","article-title":"Autoantibodies to nuclear lamin B in a patient with thrombopenia","volume":"43","author":"Guilly MN","year":"1987","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.93.1.63"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280808"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113134"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(84)90204-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.70.3.581"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","unstructured":"GeraceL ComeauC BensonM:Organization and modulation of nuclear lamina structure. J Cell Sci (suppl 1):137\u2013160 1984","DOI":"10.1242\/jcs.1984.Supplement_1.10"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-4-897"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90784-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.5.1143"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.95.3.826"},{"issue":"4","key":"e_1_2_1_18_2","first-page":"S47","article-title":"Biochemical analysis of peripheral (rim) fluorescent antinuclear antibody patterns (abstract)","volume":"30","author":"Reeves WH","year":"1987","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780311017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780311017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:42:28Z","timestamp":1700696548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780311017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1002\/art.1780311017"],"URL":"https:\/\/doi.org\/10.1002\/art.1780311017","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}