{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:03:23Z","timestamp":1790834603031,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5762,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The influence of genetic factors on the expression of CD5+ B lymphocytes and their relationship to a broad spectrum of autoantibodies was investigated in a study of 12 patients with rheumatoid arthritis (RA) and 52 of their healthy first\u2010degree relatives. The proportion of CD5+ B cells was significantly higher in RA patients (mean \u00b1 SEM 23.9 \u00b1 2.7%) compared with that in their relatives (18.3 \u00b1 1.1%; P &lt; 0.05) and compared with that in a group of healthy control subjects (16.1 \u00b1 1.8%; P &lt; 0.05). Much more striking, however, were the high levels of CD5+ B cells found in the patients and their relatives in 5 of the families studied. Increases in total immunoglobulin levels and autoantibody levels were frequently observed in RA patients (\u223c20\u201340%) and their relatives (\u223c10\u201320%). Furthermore, a statistically significant correlation (P &lt; 0.01) between IgM rheumatold factor and the percentage of B lymphocytes expressing CD5 was observed.<\/jats:p>","DOI":"10.1002\/art.1780330306","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:30:36Z","timestamp":1171495836000},"page":"339-348","source":"Crossref","is-referenced-by-count":57,"title":["The relationship between cd5\u2010expressing b lymphocytes and serologic abnormalities in rheumatoid arthritis patients and their relatives"],"prefix":"10.1002","volume":"33","author":[{"given":"P.","family":"Youinou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Katsikis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Merdrignac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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