{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:31:22Z","timestamp":1788420682389,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5762,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The constitutive production of interleukin\u20106 (IL\u20106), a potent hepatocyte\u2010stimulating factor and B cell\u2010differentiating factor, was demonstrated in 3 patients with cardiac myxomas. Tumor cells from the only patient who presented with immunologic features produced 14\u201323\u2010fold higher levels of IL\u20106 than those from the 2 patients who lacked such features. A significant serum IL\u20106 level (56 pg\/ml), greater than that observed in patients with active rheumatoid arthritis, was also observed only in this patient, with a subsequent return to an undetectable level after surgical removal of the tumor. This was associated with a regression of the immunologic features. This same patient was observed to have an IL\u20106\u2010dependent, proliferative polyclonal plasmacytosis of the bone marrow. These observations demonstrate that an overproduction of IL\u20106 by cardiac myxoma cells, in association with a systemic passage of this IL\u20106, may be responsible for the immunologic features similar to those observed in true autoimmune diseases such as rheumatoid arthritis.<\/jats:p>","DOI":"10.1002\/art.1780330313","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:30:36Z","timestamp":1171495836000},"page":"398-402","source":"Crossref","is-referenced-by-count":132,"title":["Constitutive production of interleukin\u20106 and immunologic features in cardiac myxomas"],"prefix":"10.1002","volume":"33","author":[{"given":"Michel","family":"Jourdan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Bataille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Seguin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Guang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Andr\u00e9","family":"Chaptal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90245-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310614"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830181122"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113921"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(87)90851-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91200-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/324073a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7251"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14181.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.1.228"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270521"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1182\/blood.V73.2.517.517","article-title":"A paracrine rather than autocrine regulation of myeloma cell growth and differentiation by interleukin\u20106.","volume":"13","author":"Klein B","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830181010"},{"key":"e_1_2_1_15_2","first-page":"371","article-title":"Atrial myxomas: a review of clinical experience in 40 patients.","volume":"55","author":"Sutton MG","year":"1980","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5539.547"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230216"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000206293"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.4049\/jimmunol.130.6.2597","article-title":"The role of B cell proliferation in the generation of immunoglobulin secreting cells in man.","volume":"130","author":"Jelinek DF","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/332083a0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.339"},{"key":"e_1_2_1_22_2","first-page":"1","article-title":"The bone marrow: the major source of serum immunoglobulin but still a neglected site of antibody formation.","volume":"46","author":"Benner R","year":"1981","journal-title":"Clin Exp Immunol"}],"container-title":["Arthritis &amp; 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