{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:55:49Z","timestamp":1770713749236,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5670,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mononuclear cells from BALB\/c mice with progressive polyarthritis and spondylitis induced by injection of fetal human articular cartilage proteoglycan (PG) were used to transfer arthritis by intravenous injection into irradiated, nonimmunized syngeneic mice. Successful transfer of arthritis to BALB\/c mice required the injection of lymphocytes from mice with arthritis, along with 50 m\u0308g of human fetal PG, or lymphocytes stimulated in vitro with either fetal human PG or with mouse cartilage PG. In addition, interleukin\u20102 or immune sera from animals with arthritis significantly reduced the time to onset of transferred disease. The onset of adoptively transferred arthritis, using cells and antigen, from the time of the first injection (38.2 \u00b1 18.2 days, mean \u00b1 SD) was shortened if lymphocytes from mice with transferred arthritis were reinjected (retransferred) into other, irradiated syngeneic mice (6.1 \u00b1 2.6 days). The appearance of autoreactive antibodies to mouse cartilage PG in the sera of mice with adoptively transferred arthritis (secondary or tertiary) preceded the appearance of the first clinical symptoms by a few days. The transfer of arthritis was blocked by pretreatment of donor (arthritic) lymphocytes with either anti\u2010T cell or anti\u2010B cell antibodies and complement. Exposure of mononuclear cells from mice with arthritis to PG, and its removal prior to transfer, also resulted in transfer of the arthritis. PG\u2010induced arthritis was not transferred to nonirradiated mice, nor to irradiated mice injected with lymphocytes from animals with primary arthritis without chondroitinase ABC\u2010digested fetal human PG. Arthritis never developed after injection of immune sera from mice with arthritis (without cells), nor when cells of nonarthritic animals were used with chondroitinase ABC\u2010digested fetal human PG, with or without interleukin\u20102.<\/jats:p>","DOI":"10.1002\/art.1780330614","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:27:36Z","timestamp":1171495656000},"page":"866-876","source":"Crossref","is-referenced-by-count":62,"title":["Proteoglycan\u2010induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB\/c mice"],"prefix":"10.1002","volume":"33","author":[{"given":"Katalin","family":"Mikecz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor T.","family":"Glant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edit","family":"Buz\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.Robin","family":"Poole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"316","article-title":"Changes in the collagen and proteoglycan of articular cartilage in arthritis.","volume":"10","author":"Poole AR","year":"1986","journal-title":"Rheumatology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.3.857"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748009112362"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/283666a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(81)80029-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008208209160254"},{"key":"e_1_2_1_8_2","first-page":"605","article-title":"Immunity to homologous collagens and cartilage proteoglycans in rabbits.","volume":"48","author":"Champion BR","year":"1983","journal-title":"Immunology"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300211"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300310"},{"key":"e_1_2_1_11_2","volume-title":"The Control of Tissue Damage","author":"Poole AR","year":"1988"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01967190"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310213"},{"key":"e_1_2_1_14_2","first-page":"497","article-title":"Cell\u2010mediated immunity to cartilage proteoglycan in relapsing polychondritis.","volume":"16","author":"Rajapakse DA","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190314"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808172990703"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811302992202"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90494-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1980.tb00232.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241105"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(83)90153-3"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(84)90372-1"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(88)90275-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01884.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4049\/jimmunol.140.1.78","article-title":"Isolation of T cell line capable of protecting mice against collagen\u2010induced arthritis.","volume":"140","author":"Kakimoto K","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_26_2","unstructured":".DayerE MathaiL GlantTT MikeczK PooleAR: Cartilage proteoglycan\u2010induced arthritis in BALB\/c mice: antibodies that recognize human and mouse cartilage proteoglyean and can cause depletion of cartilage proteoglycan with little or no synovitis. 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