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The antigenic perinuclear granules were found in the stratum intermedium layer of the buccal mucosa. Granules exhibited histologic features of nucleoproteins, stained for ribonucleoprotein, and showed the ultrastructural characteristics of aggregated rough endoplasmic reticulum. The antiperinuclear factor may recognize a common autoantigen in connective tissue disease.<\/jats:p>","DOI":"10.1002\/art.1780330707","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:26:57Z","timestamp":1171495617000},"page":"960-969","source":"Crossref","is-referenced-by-count":23,"title":["Histologic and electron microscopic characterization of the antiperinuclear factor antigen"],"prefix":"10.1002","volume":"33","author":[{"given":"Frederick B.","family":"Vivino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd G.","family":"Maul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0260-4639(22)00013-5","article-title":"Autoantibodies in rheumatoid arthritis: some new facts.","volume":"1","author":"Holborow E","year":"1981","journal-title":"Clin Immunol Allergy"},{"key":"e_1_2_1_3_2","volume-title":"Arthritis and Allied Conditions.","author":"Baum J","year":"1988"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.23.4.302"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780100206"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.3.248"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.3.263"},{"key":"e_1_2_1_8_2","first-page":"1346","article-title":"The diagnostic significance of the antiperinuclear factor for rheumatoid arthritis.","volume":"15","author":"Janssens X","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_2","first-page":"893","article-title":"Antiperinuclear factor: indicator of more severe disease in sero\u2010negative rheumatoid arthritis.","volume":"14","author":"Westgeest A","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","first-page":"5","article-title":"Antiperinuclear factor in Sj\u00f6gren's syndrome in the presence or absence of rheumatoid arthritis.","volume":"2","author":"Youinou P","year":"1984","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.7.446"},{"key":"e_1_2_1_12_2","first-page":"1357","article-title":"Ricerca del fattore antiperinucleare (APF) nell artrite reumatoide ed in altre malattie.","volume":"59","author":"Visconti A","year":"1964","journal-title":"Osped Maggiore"},{"key":"e_1_2_1_13_2","unstructured":".CavaL FontanaG ViscontiA: Ulteriori esperienza sul test di immufluorenza perinucleare nella diagnosi dell' artrite reumatoide \u201cAtti del Simposio Internazionale su Recenti Acquisizioni nella Terapia Antireumatica non\u2010steroidea.\u201dMinerva Med326\u2013327 1965"},{"key":"e_1_2_1_14_2","first-page":"516","article-title":"Antiperinuclear and rheumatoid factor in different forms of autoimmune thyroid disease.","volume":"55","author":"Scherbaum W","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_15_2","first-page":"60","article-title":"Evidenziazione in immunofluorescenza di un fat tore serico anti\u2010\u201cperinucleare\u201d nell artrite reumatoide.","volume":"17","author":"Del Giacco G","year":"1965","journal-title":"Reumatismo"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270464"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.39.4.381"},{"key":"e_1_2_1_18_2","volume-title":"Th. 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