{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:05:08Z","timestamp":1778947508105,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5640,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prior studies have shown that patients with rheumatoid arthritis (RA) have an increased number of circulating Epstein\u2010Barr virus\u2013infected B lymphocytes and elevated titers of antibody to Epstein\u2010Barr nuclear antigen\u20131 (EBNA\u20101), the major nuclear antigen expressed in latently infected B cells. However, it is not known whether antibodies from RA patients recognize the same epitopes as antibodies from normal subjects. Most of the anti\u2013EBNA\u20101 antibodies in normal subjects are directed at the glycine\u2010alanine repeating region of the molecule. Antibodies specific for this region are also somewhat more prevalent in RA patients than in normal subjects. A panel of synthetic peptides derived from EBNA\u20101 was used to analyze the immune response to antigenic epitopes outside the glycine\u2010alanine region, using the peptides as solid\u2010phase antigen. Sera from RA patients and from systemic lupus erythematosus patients contained elevated levels of IgG antibodies to 2 non\u2013glycine\u2010alanine peptides and to 3 non\u2013glycine\u2010alanine peptides, respectively. Two of the 3 peptides are glycinerich, but antibodies that react with them are distinct from each other, as well as from those that react with the glycine\u2010alanine epitope. Eight other peptides from the C\u2010terminal portion of EBNA\u20101 either do not react with sera or show no difference between normal subjects and patient groups. The antibodies to the glycine\u2010alanine peptide are enriched with <jats:italic>k<\/jats:italic> light chains, whereas antibodies to epitopes outside the glycinealanine region are not so restricted among <jats:italic>k<\/jats:italic> and \u03bb light chains. Thus, RA patients and systemic lupus erythematosus patients have different antibody responses than do normal subjects, both quantitatively and qualitatively.<\/jats:p>","DOI":"10.1002\/art.1780330711","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:26:57Z","timestamp":1171495617000},"page":"993-1000","source":"Crossref","is-referenced-by-count":35,"title":["Altered immune response to glycine\u2010rich sequences of epstein\u2010barr nuclear antigen\u20101 in patients with rheumatoid arthritis and systemic lupus erythematosus"],"prefix":"10.1002","volume":"33","author":[{"given":"Jorgen","family":"Petersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Roudier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"The Epstein\u2010Barr Virus: Recent Advances.","author":"Cleary M","year":"1986"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405103101905"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/329073a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.18.5665"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.4.995"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.17.6641"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.22.7207"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1429"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111388"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240601"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.4049\/jimmunol.127.5.1899","article-title":"Impaired regulation of Epstein\u2010Barr virus\u2010induced lymphocyte proliferation in rheumatoid arthritis is due to a T cell defect.","volume":"127","author":"Depper JM","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4049\/jimmunol.134.1.211","article-title":"Human immune responses to synthetic peptides from the Epstein\u2010Barr nuclear antigen.","volume":"134","author":"Rhodes G","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.4.1018"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.23.7104"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.4.270"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.4.1026"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.18.6300"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1980.tb02592.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009747909105338"},{"key":"e_1_2_1_21_2","first-page":"1","article-title":"Autoantibodies to intermediate filaments in acute viral\nhepatitis A, B, and non\u2010A non\u2010B are directed against vimentin.","volume":"19","author":"Brown C","year":"1986","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_1_22_2","first-page":"335","article-title":"Fibrillar anti\u2010cellular antibody associated with mumps and measles infection.","volume":"12","author":"Haire M","year":"1972","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1128\/jvi.57.1.397-401.1986","article-title":"Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues.","volume":"57","author":"Srinivasappa J","year":"1986","journal-title":"J Virol"}],"container-title":["Arthritis &amp; 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