{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:25:19Z","timestamp":1790929519675,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5640,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell\u2010mediated immunity has been implicated in the pathogenesis of polymyositis (PM). We conducted a prospective study in which serum levels of soluble interleukin\u20102 receptors (IL\u20102R), IL\u20101\u03b1, and IL\u20102 were correlated with creatine kinase (CK) levels and clinical disease activity. Cytokines and IL\u20102R were quantitated in 133 serum samples from 14 patients by use of an enzyme\u2010linked immunosorbent assay. In patients with acute PM (9 patients), soluble IL\u20102R and IL\u20101\u03b1 levels were elevated initially, but declined rapidly with therapy. A significant linear relationship was found between soluble IL\u20102R levels and CK levels. IL\u20102 was initially detectable in only 3 patients, and it disappeared with therapy in all 3. The levels of cytokines and IL\u20102R were consistently normal in patients with inactive PM (2 patients). In patients with chronic PM (3 patients), the cytokines and soluble IL\u20102R levels were normal despite persistently abnormal CK levels and\/or muscle weakness. Cellular IL\u20102R levels correlated positively with serum levels of soluble IL\u20102R. Our studies substantiate a pathogenic role for cellular immunity in PM, with the finding of activation of lymphocytes. The finding of increased levels of IL\u20101\u03b1 demonstrates for the first time that there is monocyte activation in PM. Persistent elevation of CK levels after normalization of the levels of cytokines and IL\u20102R may be prognostic of impending chronic disease. Serum soluble IL\u20102R appear to be a sensitive indicator of improvement or exacerbation of disease activity in patients with PM.<\/jats:p>","DOI":"10.1002\/art.1780330713","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:26:57Z","timestamp":1171495617000},"page":"1007-1014","source":"Crossref","is-referenced-by-count":43,"title":["Interleukin\u20101\u03b1, interleukin\u20102, and soluble interleukin\u20102 receptors in polymyositis"],"prefix":"10.1002","volume":"33","author":[{"given":"Robert E.","family":"Wolf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Baethge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"290","article-title":"Characterization of polymyositis infiltrates using monoclonal antibodies to human leukocyte antigens.","volume":"45","author":"Rowe DJ","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160206"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301203080307"},{"key":"e_1_2_1_5_2","first-page":"63","article-title":"Immunological aspects of polymyositis.","volume":"40","author":"Currie S","year":"1971","journal-title":"Q J Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197303012880903"},{"key":"e_1_2_1_7_2","first-page":"309","article-title":"Human muscle\u2010derived, tissue specific myocytotoxic T cell lines in dermatomyositis.","volume":"67","author":"Rosenschein U","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1974.00490390074008"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107057"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.2.182"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1978.tb00403.x"},{"key":"e_1_2_1_12_2","volume-title":"Interleukin 2: a 10\u2010year perspective, Interleukin 2.","author":"Smith KA","year":"1988"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918743"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.4049\/jimmunol.137.12.3841","article-title":"The released interleukin 2 receptor binds interleukin 2 efficiently.","volume":"137","author":"Rubin LA","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.4049\/jimmunol.139.7.2308","article-title":"A soluble interleukin 2 receptor produced by a normal alloreactive human T cell clone binds interleukin 2 with low affinity.","volume":"139","author":"Jacques Y","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310605"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780311103"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310704"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.141.8.2612","article-title":"Soluble IL\u20102 receptor in rheumatoid arthritis: correlation with disease activity, IL\u20101 and IL\u20102 inhibition.","volume":"141","author":"Symons JA","year":"1988","journal-title":"J Immunol"},{"issue":"4","key":"e_1_2_1_20_2","first-page":"S104","article-title":"Soluble interleukin\u20102 receptors in rheumatoid arthritis (abstract).","volume":"31","author":"Wolf RE","year":"1988","journal-title":"Arthritis Rheum"},{"issue":"4","key":"e_1_2_1_21_2","first-page":"S42","article-title":"Soluble interleukin\u20102 receptors in diffuse cutaneous systemic sclerosis (abstract).","volume":"32","author":"Engel EE","year":"1989","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.4049\/jimmunol.135.5.3172","article-title":"Soluble interleukin\u20102 receptors are released from activated human lymphoid cells in vitro.","volume":"135","author":"Rubin LA","year":"1985","journal-title":"J Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780330713","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780330713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T21:28:47Z","timestamp":1700774927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780330713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1990,7]]}},"alternative-id":["10.1002\/art.1780330713"],"URL":"https:\/\/doi.org\/10.1002\/art.1780330713","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7]]}}}