{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:34:58Z","timestamp":1793385298022,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T00:00:00Z","timestamp":1282003200000},"content-version":"vor","delay-in-days":7321,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Criteria for the classification of Wegener's granulomatosis (WG) were developed by comparing 85 patients who had this disease with 722 control patients with other forms of vasculitis. For the <jats:italic>traditional format classification<\/jats:italic>, 4 criteria were selected: abnormal urinary sediment (red cell casts or &gt;5 red blood cells per high power field), abnormal findings on chest radiograph (nodules, cavities, or fixed infiltrates), oral ulcers or nasal discharge, and granulomatous inflammation on biopsy. The presence of 2 or more of these 4 criteria was associated with a sensitivity of 88.2% and a specificity of 92.0%. A <jats:italic>classification tree<\/jats:italic> was also constructed with 5 criteria being selected. These criteria were the same as for the traditional format, but included hemoptysis. The classification tree was associated with a sensitivity of 87.1% and a specificity of 93.6%. We describe criteria which distinguish patients with WG from patients with other forms of vasculitis with a high level of sensitivity and specificity. This distinction is important because WG requires cyclophosphamide therapy, whereas many other forms of vasculitis can be treated with corticosteroids alone.<\/jats:p>","DOI":"10.1002\/art.1780330807","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T07:02:03Z","timestamp":1282114923000},"page":"1101-1107","source":"Crossref","is-referenced-by-count":1546,"title":["The American College of Rheumatology 1990 criteria for the classification of wegener's granulomatosis"],"prefix":"10.1002","volume":"33","author":[{"given":"Randi Y.","family":"Leavitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Fauci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat A.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene G.","family":"Hunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Arend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard H.","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Fries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. T.","family":"Lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert W.","family":"Lightfoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonse T.","family":"Masi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"McShane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Betty","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley L.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Zvaifler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"455","article-title":"Grenzformen der periarteritis Nodosa, Frankfurt","volume":"42","author":"Klinger H","year":"1931","journal-title":"Z Pathol"},{"key":"e_1_2_1_3_2","first-page":"202","article-title":"Uber generalisierte, septische Gefasser\u2010krankungen","volume":"29","author":"Wegener F","year":"1936","journal-title":"Verh Dtsch Ges Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197311000-00002"},{"key":"e_1_2_1_5_2","first-page":"1","article-title":"Pulmonary angiitis and granulomatosis","volume":"108","author":"Liebow AA","year":"1973","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_6_2","volume-title":"Wegener's granulomatosis and related diseases, Disease\u2010a\u2010Month","author":"Fauci AS","year":"1977"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-6-691"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80162-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-1-76"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90214-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330803"},{"key":"e_1_2_1_12_2","first-page":"149","article-title":"Pulmonary vasculitis","volume":"134","author":"Leavitt RY","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65300-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65312-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/art.1780330804","article-title":"Illustrated histopathologic classification criteria for selected vasculitis syndromes","volume":"33","author":"Lie JT and Members and Consultants of the American College of Rheumatology Subcommittee on Classification of Vasculitis","year":"1990","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_16_2","volume-title":"Systemic vasculitis, Current Therapy in Allergy and Rheumatology","author":"Fauci AS","year":"1988"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80174-6"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780330807","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780330807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T20:58:41Z","timestamp":1700773121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780330807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1990,8]]}},"alternative-id":["10.1002\/art.1780330807"],"URL":"https:\/\/doi.org\/10.1002\/art.1780330807","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,8]]}}}