{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:50:16Z","timestamp":1761155416290},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T00:00:00Z","timestamp":1282003200000},"content-version":"vor","delay-in-days":7321,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myositis has been associated with HLA\u2010B8 and DR3, especially in white patients with polymyositis and serum anti\u2010Jo\u20101 antibodies. Twenty\u2010eight patients with myositis and serum translation\u2010related autoantibodies anti\u2010Jo\u20101, anti\u2010PL\u20107, anti\u2010PL\u201012, anti\u2010KJ, and anti\u2010SRP were studied for HLA class II specificities by Southern blotting with HLA\u2010DR\u03b2, DQ\u03b2, and DQ\u03b1 probes. The association of HLA\u2010DR3 (DRw17) with anti\u2010Jo\u20101 antibodies in white myositis patients was confirmed (<jats:italic>P<\/jats:italic> = 0.003, relative risk 8.9). However, HLA\u2010DRw52 haplotypes, regardless of subtype, were present in all of the white and black patients with serum anti\u2010Jo\u20101 and other translation\u2010related autoantibodies. Moreover, one anti\u2010Jo\u20101 positive patient had HLA\u2010DRw8, an HLA\u2010DRw52 haplotype on which the DR\u03b23 gene has been partially deleted. No HLA\u2010DQ specificity or allele was common to all patients. The HLA\u2010DR3, DR5, DRw6, and DRw8 haplotypes, which bear the HLA\u2010DRw52 specificity, share the most homology in the DR\u03b21 first hypervariable region at amino acid positions 9\u201313. Thus, this DR\u03b21 region appears to be the most likely candidate \u201cepitope\u201d for translation\u2010related autoimmune responses in inflammatory myositis.<\/jats:p>","DOI":"10.1002\/art.1780330826","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T07:02:03Z","timestamp":1282114923000},"page":"1240-1248","source":"Crossref","is-referenced-by-count":72,"title":["HLA\u2010D Region genes associated with autoantibody responses to histidyl\u2010transfer RNA synthetase (Jo\u20101) and other translation\u2010related factors in myositis"],"prefix":"10.1002","volume":"33","author":[{"given":"Rose","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Duvic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira N.","family":"Targoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Reichlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela M.","family":"McMenemy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Reveille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noranna B.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn S.","family":"Pollack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank C.","family":"Arnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0307-742X(21)00486-0","article-title":"Juvenile dermatomyositis and polymyositis","volume":"10","author":"Pachman LM","year":"1985","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(81)90055-0"},{"key":"e_1_2_1_4_2","first-page":"925","article-title":"The Jo\u20101 antibody system in myositis: relationships to clinical features and HLA","volume":"8","author":"Arnett FC","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230802"},{"key":"e_1_2_1_6_2","volume-title":"Immunobiology of HLA, Histocompatibility Testing 1987","author":"Dupont B","year":"1989"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(88)90051-X"},{"issue":"4","key":"e_1_2_1_8_2","first-page":"S99","article-title":"Clustering of connective tissue diseases in a small Georgia community. 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A case\u2010control genetic study (abstract)","volume":"30","author":"Arnett FC","year":"1987","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780271011"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281207"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/304177a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.4049\/jimmunol.138.9.2874","article-title":"Measurement of antibody to Jo\u20101 by ELISA and comparison to enzyme inhibitory activity","volume":"138","author":"Targoff IN","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114136"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.420"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1984.tb08022.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.5.1281"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310408"},{"issue":"4","key":"e_1_2_1_21_2","first-page":"S122","article-title":"Polymyositis and antibody to signal recognition particle (abstract)","volume":"31","author":"Targoff IN","year":"1988","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01534853"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90381-6"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.12.3687"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/j.1460-2075.1983.tb01435.x","article-title":"Complete sequence of an HLA\u2010DR \u03b2 chain deduced from a cDNA clone and identification of multiple non\u2010allelic DR \u03b2 chain genes","volume":"2","author":"Long EO","year":"1982","journal-title":"EMBO J"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.7.1972"},{"key":"e_1_2_1_29_2","volume-title":"HLA class II typing by the workshop defined RFLP specificities in unrelated individuals, Immunobiology of HLA","author":"Martell M","year":"1989"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.4049\/jimmunol.139.2.562","article-title":"Molecular mapping of class II polymorphisms in the human major histocompatibility complex. 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