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Sera containing anti\u2010histone H1 antibodies were obtained from patients with systemic lupus erythematosus. Of the 9 sera tested, 2 reacted with only 1 H1 subtype. The other sera recognized different combinations of H1 subtypes. Only 1 serum reacted with all 6 H1 subtypes. Histones H1.5 and H1.1 were the subtypes most frequently recognized by the human autoantibodies. Our data indicate that human anti\u2010H1 antibodies represent a heterogenous population, directed mainly against epitopes localized in the variable region of the H1 molecule.<\/jats:p>","DOI":"10.1002\/art.1780330830","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T07:02:03Z","timestamp":1282114923000},"page":"1273-1278","source":"Crossref","is-referenced-by-count":25,"title":["Autoantibodies against different histone hi subtypes in systemic lupus erythematosus sera"],"prefix":"10.1002","volume":"33","author":[{"given":"J\u00f6zefa","family":"Wesierska\u2010Gadek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Penner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hitchman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Sauermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60836-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(88)90066-9"},{"key":"e_1_2_1_4_2","first-page":"118","article-title":"Antihistone antibodies in systemic lupus erythematosus","volume":"14","author":"Rubin RL","year":"1987","journal-title":"J Rheumatol [Suppl]"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.005343"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90303-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0021-9258(17)43713-6","article-title":"Differences in evolutionary stability among H1 subtypes: implication for the roles of H1 subtypes in chromatin","volume":"259","author":"Lennox RW","year":"1984","journal-title":"J Biol Chem"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(79)80337-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(74)31027-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)60100-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)95832-7"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2550023"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)94110-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1985.tb09319.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(88)90100-6"},{"key":"e_1_2_1_17_2","first-page":"5637","article-title":"Masking of nontumorous antigens for development of human tumor nucleolar antibodies with improved specificity","volume":"45","author":"Freemann JW","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_2","first-page":"927","article-title":"Non\u2010specific interactions of histones with serum components and contractile proteins","volume":"13","author":"Gr\u00f6schel\u2010Stewart U","year":"1986","journal-title":"Biochem Int"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.24.7410"},{"key":"e_1_2_1_20_2","first-page":"608","article-title":"Anti\u2010H1 histone antibodies in systemic lupus erythematosus: epitope localization after immunoblotting of chymotrypsin\u2010digested H1","volume":"63","author":"Costa O","year":"1986","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(87)90146-5"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(87)90101-2"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/j.2326-5205.1989.tb00019.x","article-title":"Antibodies to histones H1 and H5 in sera of patients with juvenile rheumatoid arthritis","volume":"32","author":"Pauls JD","year":"1989","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis &amp; 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