{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:01Z","timestamp":1760188861071},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5578,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirty\u2010one patients with seropositive rheumatoid arthritis treated with cyclosporin A (CsA) were evaluated for immune function prior to, during, and after 1 year of therapy. Patients whose pretreatment peripheral blood mononuclear cells were hypoproliferative in vitro to soluble recall antigens responded better clinically to CsA treatment than did the other patients. During therapy, proliferative responses became normal and remained so until 1\u20132 months after CsA was discontinued. At that time, the lymphocyte proliferation defect reappeared. In addition, patients who responded clinically to CsA had a higher percentage of Leu\u20107+ natural killer cells in their peripheral blood prior to therapy. All patients exhibited greater frequencies of cells that expressed interleukin\u20102 receptors, which decreased with CsA treatment. The clinical response to CsA appears to be associated with distinct immunologic parameters in rheumatoid arthritis.<\/jats:p>","DOI":"10.1002\/art.1780330902","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:26:06Z","timestamp":1171495566000},"page":"1310-1316","source":"Crossref","is-referenced-by-count":16,"title":["Immunologic parameters of response in patients with rheumatoid arthritis treated with cyclosporin a"],"prefix":"10.1002","volume":"33","author":[{"given":"David E.","family":"Yocum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Wilder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suanne","family":"Dougherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Klippel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Pillemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-6-810"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0889-857X(21)00927-3","article-title":"T cell regulatory disturbances in rheumatic diseases.","volume":"13","author":"Alpert SD","year":"1987","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4049\/jimmunol.133.2.697","article-title":"Immune function in severe, active rheumatoid arthritis: a relationship between peripheral blood mononuclear cell proliferation to soluble antigens and mononuclear cell subset profiles.","volume":"133","author":"Haraoui B","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(87)90126-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111526"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260904"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.16.5214"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6407112"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830150220"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-11-863"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300111"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300102"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300112"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.9.726"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.2.127"},{"key":"e_1_2_1_17_2","first-page":"175","article-title":"1958 revision of diagnostic criteria for rheumatoid arthritis.","volume":"9","author":"Ropes MW","year":"1958","journal-title":"Bull Rheum Dis"},{"issue":"4","key":"e_1_2_1_18_2","first-page":"S39","article-title":"Impaired delayed type hypersensitivity in rheumatoid arthritis reversed by chrysotherapy (abstract).","volume":"30","author":"Smith MD","year":"1987","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_19_2","first-page":"188A","article-title":"High percentage of Leu 2+ 7+ cells in the synovial fluid mononuclear cells of rheumatoid arthritis joint effusions (abstract).","volume":"36","author":"Burns CM","year":"1988","journal-title":"Clin Res"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780311003"},{"issue":"4","key":"e_1_2_1_21_2","first-page":"73","article-title":"The effects of cyclosporin A on T lymphocyte and dendritic cell subpopulations in psoriasis.","volume":"20","author":"Baker BS","year":"1988","journal-title":"Transplant Proc"},{"issue":"4","key":"e_1_2_1_22_2","first-page":"32","article-title":"Low\u2010dose cyclosporine effective in severe psoriasis: a double\u2010blind study.","volume":"20","author":"Heule F","year":"1988","journal-title":"Transplant Proc"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.5.1649"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.141.8.2612","article-title":"Soluble IL\u20102 receptor in rheumatoid arthritis: correlation with disease activity, IL\u20101 and IL\u20102 inhibition.","volume":"141","author":"Symons JA","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(89)90140-2"}],"container-title":["Arthritis &amp; 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