{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:42:28Z","timestamp":1700786548321},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5578,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The production of antibodies that react with the Fc fragment of IgG, i.e., rheumatoid factors (RF), is now regarded as a normal host immune response. It is not clear, however, if such putative physiologic RF are different from their counterparts which characterize pathologic states like rheumatoid arthritis (RA). Using <jats:italic>Staphylococcus aureus<\/jats:italic> Cowan I as an in vitro stimulant of RF production, we now report that the IgM\u2010RF secreted by blood mononuclear cells obtained from healthy newborn infants and healthy adults can be distinguished not only from classic monoclonal RF and polyclonal RA serum RF, but also from the RF secreted by blood mononuclear cells obtained from RA patients. Whereas the Fc\u2010binding activity of all RF secreted in vitro was easily inhibited by aggregated human IgG, only the RF produced by the normal umbilical cord cells and the normal adult cells were inhibited by monomeric Fc(IgG). The normal RF were also selectively inhibited by monomeric rabbit and guinea pig Fc(IgG). The RF secreted by umbilical cord blood cells utilized \u03bb and \u03bb light chains, with a disproportionate use of \u03bb light chains relative to the total IgM secreted. Together, these data provide evidence for distinct subsets of RF in health and in disease.<\/jats:p>","DOI":"10.1002\/art.1780330906","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:26:06Z","timestamp":1171495566000},"page":"1340-1346","source":"Crossref","is-referenced-by-count":3,"title":["In vitro secretion of human IgM rheumatoid factor. Evidence for Distinct Rheumatoid Factor Populations in Health and Disease"],"prefix":"10.1002","volume":"33","author":[{"given":"Niloofer","family":"Dalal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl","family":"Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold I.","family":"Levinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105758"},{"key":"e_1_2_1_3_2","first-page":"217","article-title":"Complement fixing intracellular complexes of IgG rheumatoid factor in rheumatoid plasma cells.","volume":"1","author":"Munthe E","year":"1972","journal-title":"Scand J Rheumatol"},{"key":"e_1_2_1_4_2","first-page":"249","article-title":"Characterization of IgG complexes in eluates 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