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Antibody reactivity with SRP was confirmed by enzyme\u2010linked immunosorbent assay and immunoprecipitation with isolated dog pancreas SRP. The antibody was present in the serum of 4% of PM\/DM patients, and 18% of PM\/ DM patients with anticytoplasmic antibodies other than anti\u2010Jo\u20101, but not in patients with other conditions who had anticytoplasmic antibodies. Anti\u2010SRP was associated with classic adult PM, and some of these cases were unusually severe and\/or of rapid onset; it was not found in patients with overlap syndromes or with DM involvement. Unlike patients with antibodies to aminoacyl\u2010transfer RNA synthetases, patients with anti\u2010SRP had a low frequency of pulmonary fibrosis, as well as of arthritis and Raynaud's phenomenon. Anti\u2010SRP antibodies may serve as a marker for a second, distinct subgroup of adult PM.<\/jats:p>","DOI":"10.1002\/art.1780330908","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:26:06Z","timestamp":1171495566000},"page":"1361-1370","source":"Crossref","is-referenced-by-count":270,"title":["Antibody to signal recognition particle in polymyositis"],"prefix":"10.1002","volume":"33","author":[{"given":"Ira N.","family":"Targoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur E.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick 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