{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:08:59Z","timestamp":1789819739795,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5578,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IgG antibodies against the high mobility group (HMG) nonhistone chromosomal proteins HMG\u20101 and\/or HMG\u20102 were detected in the sera of 49 (39%) of 126 antinuclear antibody (ANA)\u2010positive patients with juvenile rheumatoid arthritis (JRA), by immunoblotting. Clinical diagnosis classified these patients in 2 major groups, 105 with pauciarticular\u2010onset JRA and 21 with polyarticular\u2010onset JRA. Anti\u2010HMG\u20101 and\/or anti\u2010HMG\u20102 antibodies were found in 8 (25%) of 32 pauciarticular\u2010onset JRA patients with uveitis and in 34 (47%) of 73 patients without uveitis, whereas anti\u2010HMG\u20101 and\/or anti\u2010HMG\u20102 antibodies were found in 4 (24%) of 17 children with polyarticular\u2010onset JRA without uveitis. Among 53 sera from ANA\u2010negative JRA patients, 3 (6%) were positive for anti\u2010HMG\u20101 and\/or anti\u2010HMG\u20102 antibodies, whereas no reactivity to HMG\u20101 or HMG\u20102 proteins was observed in 48 sera from age\u2010matched children with nonrheumatic diseases.<\/jats:p>","DOI":"10.1002\/art.1780330910","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:26:06Z","timestamp":1171495566000},"page":"1378-1383","source":"Crossref","is-referenced-by-count":59,"title":["Autoantibodies to nonhistone chromosomal proteins HMG\u20101 and HMG\u20102 in sera of patients with juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"33","author":[{"given":"Bettina","family":"Wittemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Neuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Michels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Truckenbrodt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedlinde 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patients with juvenile rheumatoid arthritis.","volume":"32","author":"Pauls JD","year":"1989","journal-title":"Arthritis Rheum"},{"issue":"2","key":"e_1_2_1_15_2","first-page":"195","article-title":"Current proposed revision of JRA criteria.","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_16_2","volume-title":"The HMG Chromosomal Proteins.","author":"Nicolas 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