{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:36:43Z","timestamp":1791229003155,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5578,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have characterized autoantibodies to nuclear and nucleolar antigens in 112 patients with diffuse scleroderma, CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias), scleroderma overlap syndromes, or primary Raynaud's phenomenon by indirect immunofluo\u2010rescence and radiolabeled immunoprecipitation assays. We noted for the first time that anti\u2010Th RNP antibodies represent a common antibody specificity in scleroderma (occurring in 13% of patients with scleroderma\u2010like illnesses) and that anti\u2010NOR 90 antibodies are quite rare in American patients (none found). In addition, we describe 3 new scleroderma\u2010associated autoantibodies.<\/jats:p>","DOI":"10.1002\/art.1780330917","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:26:06Z","timestamp":1171495566000},"page":"1431-1437","source":"Crossref","is-referenced-by-count":69,"title":["The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays"],"prefix":"10.1002","volume":"33","author":[{"given":"Robert J.","family":"Kipnis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Craft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Hardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230602"},{"key":"e_1_2_1_3_2","first-page":"43","article-title":"Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis.","volume":"48","author":"Bernstein RM","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1627"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90462-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310207"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310409"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310309"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260101"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270202"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-74-5-714"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113511"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.139.8.2579","article-title":"Anti\u2010NOR 90: a new autoantibody in scleroderma that recognizes a 90\u2010kDa component of the nucleolus\u2010organizing region of chromatin.","volume":"139","author":"Rodriguez\u2010Sanchez JL","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","first-page":"227","article-title":"Association of anti\u2010centromere and anti\u2010Scl 70 antibodies in scleroderma: report of two cases.","volume":"16","author":"Ruffatti A","year":"1985","journal-title":"J Clin Lab Immunol"},{"issue":"4","key":"e_1_2_1_17_2","article-title":"Antibodies to ribonucleoproteins in SLE (abstract).","volume":"31","author":"Evans J","year":"1988","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_18_2","first-page":"366","article-title":"Antibodies against Ku protein in sera from patients with autoimmune diseases.","volume":"76","author":"Yaneva M","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112320"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00915286"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110295"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110587"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5483"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2476849"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90126-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00360432"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00360435"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112809"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.4049\/jimmunol.137.12.3802","article-title":"Immunolocalization and partial characterization of a nucleolar autoantigen (PM\u2010Scl) associated with polymyositis\/scleroderma overlap syndromes.","volume":"137","author":"Reimer G","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.8.2899"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.11.5495"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3003910"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780330917","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780330917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T21:46:28Z","timestamp":1700775988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780330917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1002\/art.1780330917"],"URL":"https:\/\/doi.org\/10.1002\/art.1780330917","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}