{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T20:47:46Z","timestamp":1700686066949},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5548,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Urinalyses of randomly obtained samples from children with various types of chronic arthritis revealed proteinuria in 2.3% of patients, hemoglobinuria in 3.5%, erythrocyturia in 4.1%, and leukocyturia in 5.3%; these frequencies are within the range found by screening school children. However, raised urinary levels of <jats:italic>N<\/jats:italic>\u2010acetyl\u2010\u03b2\u2010glucosaminidase and\/or \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin (both sensitive measures of renal tubular damage) were found more frequently in children with chronic arthritis than in controls (<jats:italic>P<\/jats:italic> &lt; 0.0001). Abnormalities of either <jats:italic>N<\/jats:italic>\u2010acetyl\u2010\u03b2\u2010glucosaminidase or \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin excretion were associated with active arthritis as measured by physician global estimate of disease activity, with a polyarticular onset of juvenile rheumatoid arthritis, and with the use of slow\u2010acting antirheumatic drugs or the concurrent use of more than 1 nonsteroidal antiinflammatory drug. Abnormal renal tubular function appears to be common in chronic arthritis of childhood. The long\u2010term consequences of this abnormality remain to be elucidated.<\/jats:p>","DOI":"10.1002\/art.1780331014","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:04:17Z","timestamp":1171494257000},"page":"1560-1566","source":"Crossref","is-referenced-by-count":10,"title":["Renal disease in chronic arthritis of childhood. 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