{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:09:35Z","timestamp":1761487775898},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5548,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a patient who presented with polyarthritis, pleurisy, rash, and a positive antinuclear antibody result after 5 years of D\u2010penicillamine therapy. D\u2010penicillamine\u2010induced antinuclear antibodies were mainly high\u2010titer IgG directed against the (H2A\u2010H2B)\u2010DNA complex. Weak IgM activity with H1 and H2B was also observed. Withdrawal of D\u2010penicillamine therapy resulted in improvement in clinical symptoms and gradual resolution of serologic abnormalities.<\/jats:p>","DOI":"10.1002\/art.1780331018","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:04:17Z","timestamp":1171494257000},"page":"1582-1585","source":"Crossref","is-referenced-by-count":35,"title":["D\u2010penicillamine\u2010induced lupus erythematosus"],"prefix":"10.1002","volume":"33","author":[{"given":"Raymond J.","family":"Enzenauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sterling G.","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0307-742X(21)00203-4","article-title":"Drug\u2010induced lupus: clinical and serological studies.","volume":"8","author":"Harmon CE","year":"1982","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-659"},{"key":"e_1_2_1_4_2","volume-title":"Manual of Clinical Laboratory Immunology.","author":"Rubin RL","year":"1986"},{"key":"e_1_2_1_5_2","first-page":"80","article-title":"Autoantibody formation in d\u2010penicillamine\u2010treated rheumatoid arthritis.","volume":"7","author":"Camus JP","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000250283"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-75-3-427"},{"key":"e_1_2_1_8_2","first-page":"155","article-title":"Penicillamine and the SLE syndrome.","volume":"8","author":"Walshe JM","year":"1981","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.220.4.588"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-6-1012_1"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(82)90166-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806023182204"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-6-840"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320214"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60641-0"},{"key":"e_1_2_1_16_2","first-page":"213","article-title":"Induction of DNA\u2010antibodies by d\u2010penicillamine.","volume":"3","author":"Webb J","year":"1985","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.5.408"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240814"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109161"},{"issue":"4","key":"e_1_2_1_20_2","first-page":"S22","article-title":"Anti\u2010histone antibody induction by drugs implicates autoimmunization with nucleohistone (abstract).","volume":"32","author":"Burlingame RW","year":"1989","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780331018","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780331018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T20:13:57Z","timestamp":1700684037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780331018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["10.1002\/art.1780331018"],"URL":"https:\/\/doi.org\/10.1002\/art.1780331018","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]}}}