{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:15:56Z","timestamp":1761016556729},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5517,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homogenates of 6 samples of human osteoarthritic cartilage were shown to degrade exogenous type XI collagen. On sodium dodecyl sulfate\u2010polyacrylamide gel electrophoresis, the cleavage products generated by each homogenate were similar, and they were identical to those obtained by cleavage of the substrate with purified gelatinase. Enzyme activity, which was inhibited by EDTA, was greater in extracts of fibrillated osteoarthritic cartilage than in extracts of grossly normal cartilage from the same joint or in extracts of cartilage from joints with osteonecrosis. Activation with APMA enhanced digestion, but breakdown was apparent in extracts of fibrillated osteoarthritic cartilage even without APMA. Enzymatic degradation of type XI collagen could play a significant role in the turnover of articular cartilage in health and disease states.<\/jats:p>","DOI":"10.1002\/art.1780331104","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:04:05Z","timestamp":1171494245000},"page":"1626-1633","source":"Crossref","is-referenced-by-count":16,"title":["Type XI collagen\u2010degrading activity in human osteoarthritic cartilage"],"prefix":"10.1002","volume":"33","author":[{"suffix":"Jr","given":"Lucino P.","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Gerald N.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Capello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(79)80024-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-481280-2.50013-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320302"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(82)80949-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.5.575"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"10761","DOI":"10.1016\/S0021-9258(19)85146-3","article-title":"Interaction of proteoglycans with the pericellular (1\u03b1, 2\u03b1, 3\u03b1) collagens of cartilage.","volume":"260","author":"Smith GN","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108632"},{"key":"e_1_2_1_9_2","first-page":"30","article-title":"The role of proteases in the pathogenesis of osteoarthritis.","volume":"14","author":"Ehrlich MG","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197153030-00009"},{"key":"e_1_2_1_11_2","first-page":"43","article-title":"Levels of metalloproteases and tissue inhibitor of metalloproteases in human osteoarthritic cartilage.","volume":"14","author":"Dean DD","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260110"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1990807"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(82)90664-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(84)91454-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0889-857X(21)00843-7","article-title":"Biochemical mechanisms of articular destruction.","volume":"13","author":"Mainardi CL","year":"1987","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(72)90249-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/S0021-9258(18)89580-1","article-title":"Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.","volume":"260","author":"Hibbs MS","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_1_19_2","unstructured":".SmithGNJr HastyKA YuLPJr LambersonKS MicklerEA BrandtKD:Cleavage of type XI collagen fibers by gelatinase and by extracts of osteoarthritic canine cartilage.Submitted for publication"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(82)82102-2"},{"key":"e_1_2_1_21_2","first-page":"7852","article-title":"Human cartilage collagens.","volume":"257","author":"Burgeson RE","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(61)90291-0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/clinchem\/25.9.1572","article-title":"Enhancement of immune cellular agglutination by use of an avidin\u2010biotin system.","volume":"25","author":"Costello SM","year":"1979","journal-title":"Clin Chem"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160207"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281212"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197401032900101"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102092"},{"key":"e_1_2_1_29_2","first-page":"295","article-title":"Dog cartilage in osteoarthritis: matrix and mechanical properties (abstract).","volume":"5","author":"Altman RD","year":"1980","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780331104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780331104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T21:36:22Z","timestamp":1700688982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780331104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["10.1002\/art.1780331104"],"URL":"https:\/\/doi.org\/10.1002\/art.1780331104","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}