{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:22:37Z","timestamp":1770794557969,"version":"3.50.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5487,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied sera of 371 consecutive new patients with systemic sclerosis (SSc; scieroderma) who were first evaluated during 1984\u20131988. All sera were tested for antinuclear antibodies by immunofluorescence staining using HEp\u20102 cells as substrate. We excluded 219 sera showing dark nucleoli and screened for antibodies to Th in the remaining 152 sera by immunoprecipitation of a <jats:sup>32<\/jats:sup>P\u2010labeled HeLa cell extract. Fifteen (4.0%) of 371 sera were anti\u2010Th+. Anti\u2010Th antibodies were present in 14 (8.4%) of 167 SSc patients with limited cutaneous involvement, in 1 of 167 with diffuse cutaneous involvement, and in 0 of 37 with SSc overlap syndrome. Among 244 controls with other connective tissue diseases, anti\u2010Th was detected in only 3 patients, all having primary Raynaud's phenomenon of 2 years duration. In the subgroup with SSc with limited cutaneous involvement, the 14 anti\u2010Th+ patients had a significantly greater frequency of puffy fingers, small bowel involvement, and hypothyroidism, and a significantly lower frequency of arthralgia and\/or arthritis. Their cumulative survival rate from the time of onset of symptoms was lower than that for anti\u2010Th\u2014 patients (78% versus 91% at 10 years), primarily due to 3 deaths from pulmonary arterial hypertension (2 from primary pulmonary hypertension and 1 from pulmonary hypertension secondary to pulmonary interstitial fibrosis). Serum anti\u2010Th antibodies are present almost exclusively in patients with SSc with limited cutaneous involvement or in those with primary Raynaud's phenomenon whose disease may evolve to SSc with limited cutaneous involvement, and these antibodies may identify those patients who are at greater risk for reduced survival.<\/jats:p>","DOI":"10.1002\/art.1780331210","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:03:54Z","timestamp":1171494234000},"page":"1822-1828","source":"Crossref","is-referenced-by-count":99,"title":["Autoantibody to th ribonucleoprotein (nucleolar 7\u20132 rna protein particle) in patients with systemic sclerosis"],"prefix":"10.1002","volume":"33","author":[{"given":"Yutaka","family":"Okano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Thomas A.","family":"Medsger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Arthritis and Allied Conditions.","author":"Medsger TA","year":"1989"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0307-742X(21)00050-3","article-title":"Classification and nomenclature of progressive systemic sclerosis (scleroderma).","volume":"5","author":"Rodnan GP","year":"1979","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60836-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3003910"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310207"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310309"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.1.23"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270202"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90462-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260101"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310409"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110587"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0021-9258(18)32991-0","article-title":"Detection of a nucleolar 7\u20102 ribonucleoprotein and cytoplasmic 8\u20102 ribonucleoprotein with autoantibodies from patients with scleroderma.","volume":"258","author":"Reddy R","year":"1983","journal-title":"J Biol Chem"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0021-9258(18)32990-9","article-title":"Sequential association of nucleolar 7\u20102 RNA with two different autoantigens.","volume":"258","author":"Hashimoto C","year":"1983","journal-title":"J Biol Chem"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5483"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2476849"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-652"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-74-5-714"},{"key":"e_1_2_1_21_2","volume-title":"Methods in Immunology.","author":"Garvey JS","year":"1977"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251102"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330917"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780331210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780331210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T21:26:10Z","timestamp":1700688370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780331210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["10.1002\/art.1780331210"],"URL":"https:\/\/doi.org\/10.1002\/art.1780331210","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}