{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:09:13Z","timestamp":1760954953281},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5456,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe 4 children with seronegative inflammatory arthritis who had persistent, severe nausea and abdominal pain over several months, in spite of vigorous medical therapy, including antacids and histamine H<jats:sub>2<\/jats:sub> receptor antagonists. Endoscopy and biopsy of gastric and duodenal mucosa showed antral gastritis and an increased number of mast cells in 3 of the 4 patients. In the fourth patient, urinary histamine levels were elevated. These findings suggest an association between inflammatory arthritis and localized mast cell disease in some individuals. Further studies are needed to determine whether this association represents an independent syndrome or whether mast cell\u2013related disease is secondary to long\u2010term treatment with nonsteroidal antiinflammatory drugs in children with mild arthritis.<\/jats:p>","DOI":"10.1002\/art.1780340117","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:45:43Z","timestamp":1171496743000},"page":"106-109","source":"Crossref","is-referenced-by-count":9,"title":["Seronegative juvenile rheumatoid arthritis and mast cell\u2013associated gastritis"],"prefix":"10.1002","volume":"34","author":[{"given":"Carol B.","family":"Lindsley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Philip B.","family":"Miner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1908","article-title":"New approaches for the analysis of mast cell maturation, heterogeneity and function","volume":"76","author":"Galli SJ","year":"1987","journal-title":"FASEB J"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198701000-00013"},{"key":"e_1_2_1_4_2","first-page":"A329","article-title":"Clinical presentation of patients with increased antral mast cells (abstract)","volume":"96","author":"Matter SE","year":"1989","journal-title":"Gastroenterology"},{"key":"e_1_2_1_5_2","first-page":"36","article-title":"Mastocytosis without urticaria pigmentosa: a frequently unrecognized cause of recurrent syncope","volume":"95","author":"Roberts LJ","year":"1982","journal-title":"Trans Assoc Am Physicians"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90385-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.8.851"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0016-5085(88)80012-X","article-title":"Gastrointestinal dysfunction in systemic mastocytosis: a prospective study","volume":"95","author":"Cherner JA","year":"1988","journal-title":"Gastroenterology"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90627-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270802"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270803"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290803"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012113032405"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198806000-00011"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80471-7"},{"issue":"2","key":"e_1_2_1_16_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780340117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780340117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:57:51Z","timestamp":1700762271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780340117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/art.1780340117"],"URL":"https:\/\/doi.org\/10.1002\/art.1780340117","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}