{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T19:24:09Z","timestamp":1766690649406},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5425,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the effect of tenidap sodium, a new antiinflammatory\/antirheumatic drug (120 mg\/day for 7 days), on eicosanoid production and neutrophil degranulation in patients with rheumatoid arthritis. Endogenous prostaglandin E<jats:sub>2<\/jats:sub> levels and ex vivo production of leukotriene B<jats:sub>4<\/jats:sub> (LTB<jats:sub>4<\/jats:sub>) were measured in synovial fluid samples obtained at baseline and 1 week later. We measured peripheral blood polymorphonuclear cell (PMN) degranulation following surface\u2010bound IgG stimulation, a possible 5\u2010lipoxygenase product\u2013mediated event, by determining lactoferrin and elastase release into the culture fluid. We found decreased levels of endogenous prostaglandin E<jats:sub>2<\/jats:sub> as measured by radioimmunoassay, and decreased ex vivo production of LTB<jats:sub>4<\/jats:sub> by PMN as measured by high performance liquid chromatography, in synovial fluid samples from patients who took tenidap. Release of the granule proteins lactoferrin and elastase was decreased in PMN obtained from patients receiving tenidap, as well as in the PMN incubated in vitro with tenidap. Improvement in clinical measures paralleled the biochemical changes. The unique 5\u2010lipoxygenase inhibitory property of tenidap, as measured by LTB<jats:sub>4<\/jats:sub> production and degranulation, suggests that it may have clinical activity which differentiates it from nonsteroidal antiinflammatory drugs.<\/jats:p>","DOI":"10.1002\/art.1780340212","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:43:48Z","timestamp":1171496628000},"page":"204-210","source":"Crossref","is-referenced-by-count":44,"title":["Inhibition of 5\u2010lipoxygenase product formation and polymorphonuclear cell degranulation by tenidap sodium in patients with rheumatoid arthritis"],"prefix":"10.1002","volume":"34","author":[{"suffix":"Jr.","given":"Warren D.","family":"Blackburn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis W.","family":"Heck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leland D.","family":"Loose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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