{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:34:58Z","timestamp":1771007698853,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5397,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010nine female patients with fibromyalgia were questioned about symptoms of cold intolerance and Raynaud's syndrome; objective documentation of cold\u2010induced vasospasm was obtained by a Nielsen test. Twelve patients (41%) had abnormal Nielsen test results, and 11 patients (38%) had elevated levels of platelet \u03b1<jats:sub>2<\/jats:sub>\u2010adrenergic receptors. There was a positive correlation between the percentage of change in finger systolic pressure on cooling (Nielsen test) and the number of \u03b1<jats:sub>2<\/jats:sub>\u2010adrenergic receptors. There was poor correlation between Raynaud's syndrome symptoms and an abnormal Nielsen test result. Digital photoplethysmography showed a normal waveform in 2 of 3 patients. We hypothesize that a subgroup of patients with fibromyalgia syndrome have an up\u2010regulation of \u03b1<jats:sub>2<\/jats:sub>\u2010adrenergic receptors as a cause of their exaggerated reaction to cold.<\/jats:p>","DOI":"10.1002\/art.1780340303","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:43:44Z","timestamp":1171496624000},"page":"264-269","source":"Crossref","is-referenced-by-count":57,"title":["Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet \u03b1<sub>2<\/sub>\u2010adrenergic receptors"],"prefix":"10.1002","volume":"34","author":[{"given":"Robert M.","family":"Bennett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon R.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley B.","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol S.","family":"Burckhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna L.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390200122026"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(21)00029-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.4.317"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748609092601"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_1_7_2","first-page":"58","article-title":"Confounding features of the fibromyalgia syndrome: a current perspective of differential diagnosis","volume":"16","author":"Bennett RM","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90019-X"},{"key":"e_1_2_1_9_2","first-page":"368","article-title":"A prospective evaluation of 118 patients with the fibromyalgia syndrome: prevalence of Raynaud's phenomenon, sicca symptoms, ANA, low complement, and Ig deposition at the dermal\u2013epidermal junction","volume":"13","author":"Dinerman H","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320415"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1977.43.5.907"},{"key":"e_1_2_1_12_2","first-page":"34","article-title":"The non\u2010invasive quantification of digital vasospasm","volume":"8","author":"Gates K","year":"1984","journal-title":"Bruit"},{"key":"e_1_2_1_13_2","first-page":"19","article-title":"Vascular laboratory evaluation of Raynaud's syndrome","volume":"5","author":"Holmgren K","year":"1981","journal-title":"Bruit"},{"key":"e_1_2_1_14_2","first-page":"38","article-title":"Alpha\u2010adrenergic receptor levels in obstruc and spastic Raynaud's syndrome","volume":"5","author":"Edwards J","journal-title":"J Vasc Surg"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90873-9"},{"key":"e_1_2_1_17_2","volume-title":"Cutaneous vascular diseases, Andrews' Diseases of the Skin. 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