{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:02:45Z","timestamp":1762160565421},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5336,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the lymphocyte proliferative response to <jats:italic>Chlamydia trachomatis<\/jats:italic> in Reiter's syndrome (RS) compared with that in other rheumatic diseases. RS patients showed significantly increased <jats:italic>C trachomatis<\/jats:italic>\u2013specific synovial fluid (SF) T cell proliferation. Proliferating cells were found in both CD4+ and CD8+ T cell subsets. The SF lymphocyte proliferative response to <jats:italic>C trachomatis<\/jats:italic> in RS was inhibited by anti\u2013class I and class II major histocompatibility complex monoclonal antibodies, while the response to tuberculin purified protein derivative was inhibited only by anti\u2013class II monoclonal antibodies. T cell receptor \u03b3\/\u03b4\u2013bearing T cells were not consistently increased in RS SF compared with peripheral blood, nor did such cells consistently expand upon in vitro culture with <jats:italic>C trachomatis<\/jats:italic>. Finally, there was no correlation between the cellular immune response and levels of antibody to <jats:italic>C trachomatis<\/jats:italic> antigens. Our results indicate that a specific T cell response to <jats:italic>C trachomatis<\/jats:italic> within the joint plays a role in the pathogenesis of RS.<\/jats:p>","DOI":"10.1002\/art.1780340511","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:40:41Z","timestamp":1171496441000},"page":"588-598","source":"Crossref","is-referenced-by-count":58,"title":["Synovial T lymphocyte\u2013specific immune response to <i>Chlamydia trachomatis<\/i> in Reiter's disease"],"prefix":"10.1002","volume":"34","author":[{"given":"Joachim","family":"Sieper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Kingsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Palacios\u2010Boix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Pitzalis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel S.","family":"Panayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Treharne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Keat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312293092604"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.39.5.431"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91910-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.4.295"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310801"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91091-X"},{"key":"e_1_2_1_8_2","first-page":"751","article-title":"Cell\u2010mediated immune response of synovial mononuclear cells in Reiter's syndrome against ureaplasmal and chlamydial antigens","volume":"7","author":"Ford DK","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240612"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/12.3.115"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-123-2-197"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.6.510"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1988.tb02435.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(87)90364-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812013192203"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.34.1.98-104.1981"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91292-3"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.12.852"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.4.903"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/339342a0"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90305-8"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(88)90002-9"},{"key":"e_1_2_1_24_2","first-page":"74","article-title":"T gamma delta cells in rheumatoid arthritis (abstract)","volume":"28","author":"Smith MD","year":"1989","journal-title":"Br J Rheumatol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/29.1.58"}],"container-title":["Arthritis &amp; 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