{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:15:06Z","timestamp":1791400506139,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5305,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Among 6 patients with prolonged episodes of Lyme arthritis, the mean response of peripheral blood lymphocytes (PBL) to all <jats:italic>Borrelia burgdorferi<\/jats:italic> antigens (stimulation index [SI] 46) was greater than that among 5 patients with brief attacks of Lyme arthritis (SI 13; <jats:italic>P<\/jats:italic> &lt; 0.1), as well as that among 7 control patients with rheumatoid arthritis and among 6 normal control subjects (in both instances SI 3; <jats:italic>P<\/jats:italic> &lt; 0.05). In individual patients with brief episodes of Lyme arthritis, PBL had similar low levels of reactivity with the 20\u2010kd, 31\u2010kd, 34\u2010kd, 41\u2010kd, 55\/58\u2010kd, and 66\u2010kd spirochetal polypeptides. In individual patients with prolonged arthritis, PBL usually had similar marked responsiveness to the 34\u2010kd, 41\u2010kd, 55\/58\u2010kd, and 66\u2010kd polypeptides, but they had greater reactivity with the 34\u2010kd outer surface protein B than with the 31\u2010kd outer surface protein A (<jats:italic>P<\/jats:italic> &lt; 0.05). In the 2 patients tested, paired samples of synovial fluid lymphocytes and PBL had a similar pattern of reactivity, but the response was 2\u2013100\u2010fold greater in synovial fluid lymphocytes. We conclude that patients with prolonged Lyme arthritis have T cell responses to multiple spirochetal polypeptides.<\/jats:p>","DOI":"10.1002\/art.1780340611","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:40:35Z","timestamp":1171496435000},"page":"707-713","source":"Crossref","is-referenced-by-count":39,"title":["T cell responses to polypeptide fractions of <i>Borrelia burgdorferi<\/i> in patients with lyme arthritis"],"prefix":"10.1002","volume":"34","author":[{"given":"Natalino H.","family":"Yoshinari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce N.","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Steere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210906"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-5-725"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-6-896"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230511"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.154.1.3964949"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230402"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121401"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198303313081301"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112683"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110998"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290609"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90352-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb31843.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.11.1642"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1128\/iai.52.2.549-554.1986","article-title":"A Borrelia\u2010specific monoclonal antibody binds to a flagellar epitope","volume":"52","author":"Barbour AG","year":"1986","journal-title":"Infect Immun"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114157"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1128\/iai.56.8.2047-2053.1988","article-title":"Immunochemical characterization of and isolation of the gene for a Borrelia burgdorferi immunodominant 60\u2010kilodalton antigen common to a wide range of bacteria","volume":"56","author":"Hansen K","year":"1988","journal-title":"Infect Immun"},{"key":"e_1_2_1_19_2","unstructured":"LauxDC NelsonDR:Reactivity of Lyme disease patient sera against heat shock proteins of Borrelia burgdorferi(abstract). IV International Conference on Lyme Borreliosis Stockholm Sweden June 18\u201321 1990"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.41.2.795-804.1983"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1989.tb00194.x"},{"key":"e_1_2_1_22_2","first-page":"790","article-title":"The antibody response in Lyme disease: evaluation of diagnostic tests","volume":"157","author":"Craft JE","year":"1988","journal-title":"J Infect Dis"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.4.790"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(87)90429-7"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.4049\/jimmunol.142.10.3599","article-title":"Molecular study of the T cell repertoire in family contacts and patients with leprosy","volume":"142","author":"Mendez\u2010Samperio P","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_1_26_2","first-page":"1","article-title":"A novel approach to the identification of T\u2010cell epitopes in Mycobacterium tuberculosis using human T\u2010lymphocyte clones","volume":"60","author":"Lamb JR","year":"1987","journal-title":"Immunology"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1128\/iai.58.5.1461-1470.1990","article-title":"Crossreactivity and sequence homology between the 65\u2010kilodalton mycobacterial heat shock protein and human lactoferrin, transferrin, and DR subsets of major histocompatibility complex class II molecules","volume":"58","author":"Aguas AP","year":"1990","journal-title":"Infect Immun"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1695022"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb31846.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1128\/iai.57.9.2733-2741.1989","article-title":"Clonal polymorphisms of outer membrane protein OspB of Borrelia burgdorferi","volume":"57","author":"Bundoc VG","year":"1989","journal-title":"Infect Immun"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780340611","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780340611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:53:31Z","timestamp":1700758411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780340611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["10.1002\/art.1780340611"],"URL":"https:\/\/doi.org\/10.1002\/art.1780340611","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}