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Anti\u2010Ro\u2010positive sera may contain either or both of 2 sets of antibodies, recognizing either a 60\u2010kd or a 52\u2010kd polypeptide component of the Ro particle. We found in this study that the immune response to the 60\u2010kd Ro antigen is heterogeneous. Some sera specifically recognize the native Ro antigen but fail to bind the corresponding denatured polypeptides. In addition, after immunodepletion using the denatured 60\u2010kd Ro polypeptide, all anti\u2010Ro\u2010positive sera tested still contained high titers of antibodies recognizing conformational determinants on the Ro antigen. The frequent immunodominance of anti\u2010Ro antibodies targeted to conformational determinants suggests that native autoantigens may directly drive the autoimmune response.<\/jats:p>","DOI":"10.1002\/art.1780340613","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:40:35Z","timestamp":1171496435000},"page":"722-730","source":"Crossref","is-referenced-by-count":98,"title":["Sera from patients with autoimmune disease recognize conformational determinants on the 60\u2010kd ro\/ss\u2010a 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