{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:10:41Z","timestamp":1700759441162},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5305,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined synovial fluid samples from 14 patients with Lyme arthritis for the presence of neutrophil chemotactic factors. Thirteen of the synovial fluids stimulated chemotaxis of normal human neutrophils. The chemotactic activity was heat\u2010sensitive and was not inhibited by antibody to C5a or antibody to interleukin\u20108, or by a competitive inhibitor of the chemotactic peptide f\u2010Met\u2010Leu\u2010Phe. A culture supernatant of <jats:italic>Borrelia burgdorferi<\/jats:italic> also contained neutrophil chemoattractants. Chromatography demonstrated that the chemoattractants in the synovial fluid samples were different from those in the <jats:italic>B burgdorferi<\/jats:italic> culture supernatant. One of the major chemotactic factors in Lyme disease synovial fluid had a calculated molecular weight of 13,900. We conclude that a novel, host\u2010derived chemoattractant is present in the synovial fluid of patients with Lyme disease.<\/jats:p>","DOI":"10.1002\/art.1780340620","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:40:35Z","timestamp":1171496435000},"page":"770-775","source":"Crossref","is-referenced-by-count":12,"title":["Neutrophil chemotactic factors in synovial fluids of patients with lyme disease"],"prefix":"10.1002","volume":"34","author":[{"given":"Kostis","family":"Georgilis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Noring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen C.","family":"Steere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Klempner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210906"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-6-685"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-6-896"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310405"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb31841.x"},{"key":"e_1_2_1_7_2","volume-title":"Pathogenesis of rheumatoid arthritis: a disorder associated with dysfunctional immunoregulation, Inflammation: Basic Principles and Clinical Correlates","author":"Harris ED","year":"1988"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30951-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109947"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748809102971"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.4049\/jimmunol.138.10.3403","article-title":"Human recombinant interleukin 1\u03b2 has no effect on intracellular calcium or on functional responses of human neutrophils","volume":"138","author":"Georgilis K","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1182\/blood.V55.6.898.898","article-title":"Granulocyte aggregometry: a sensitive technique for the detection of C5a and complement activation","volume":"55","author":"Hammerschmidt DE","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_13_2","first-page":"521","article-title":"Isolation and cultivation of Lyme disease spirochetes","volume":"57","author":"Barbour AG","year":"1984","journal-title":"Yale J Biol Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb31893.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb31845.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114265"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780340620","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780340620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:53:14Z","timestamp":1700758394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780340620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["10.1002\/art.1780340620"],"URL":"https:\/\/doi.org\/10.1002\/art.1780340620","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}