{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:44:24Z","timestamp":1773038664937,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5275,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elevated serum levels of IgA, IgA1, and IgA2 rheumatoid factors (RF) were demonstrated by enzymelinked immunosorbent assay in 69%, 73%, and 36%, respectively, of 100 patients with rheumatoid arthritis (RA), whereas fewer than 5% of 100 healthy donor sera contained elevated levels of these RFs. In serum samples from 125 controls with 4 different chronic diseases (systemic lupus erythematosus, ankylosing spondylitis, bronchial asthma, and polyarteritis nodosa), levels of IgA\u2010, IgA1\u2010, and IgA2\u2010RF were found to be increased in 7%, 7%, and 8%, respectively. Comparison of RF levels in samples of serum, synovial fluid (SF), and saliva from RA patients indicated local production of both IgA\u2010RF subclasses in salivary glands and in synovial tissue. Significant positive correlations were found between levels of IgA\u2010RF subclasses in SF and serum, but not in serum and saliva or in SF and saliva. Fractionation of serum, SF, and saliva from patients with RA (by high performance liquid chromatography under acidic conditions) demonstrated that both IgA subclasses with RF activity occur mainly in fractions that also contain IgM. The results of this study show that 1) IgA\u2010RF in serum and SF is mainly of IgA1 subclass, 2) both IgA\u2010RF subclasses are produced locally in salivary glands and in synovial tissue, 3) the production of both IgA\u2010RF subclasses at mucosal and nonmucosal sites is independent from each other, and 4) both IgA\u2010RF subclasses occur predominantly in polymeric form in serum, SF, and saliva in RA patients.<\/jats:p>","DOI":"10.1002\/art.1780340708","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:40:30Z","timestamp":1171496430000},"page":"831-839","source":"Crossref","is-referenced-by-count":13,"title":["Subclass distribution and size of human IgA rheumatoid factor at mucosal and nonmucosal sites"],"prefix":"10.1002","volume":"34","author":[{"given":"Henny G.","family":"Otten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed R.","family":"Daha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob M.","family":"Van Laar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hennie H.","family":"De Rooy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand C.","family":"Breedveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(76)90094-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","unstructured":"TeitssonI: IgA rheumatoid factor as predictor of disease activity.Scand J RheumatolSuppl 75:233\u2013237 1988","DOI":"10.3109\/03009748809096769"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.5.380"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02274780"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(86)90073-5"},{"key":"e_1_2_1_7_2","first-page":"383","article-title":"IgA subclasses in various secretions and in serum","volume":"7","author":"Delacroix DL","year":"1982","journal-title":"Immunology"},{"key":"e_1_2_1_8_2","first-page":"75","article-title":"IgA and IgM rheumatoid factors in serum, saliva and other secretions: relationship to immunoglobulin ratios in systemic sicca syndrome and rheumatoid arthritis","volume":"52","author":"Elkon KB","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820138809052958"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/28.4.310"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(84)90160-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291003"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749009096788"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281105"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02274839"},{"key":"e_1_2_1_17_2","first-page":"379","article-title":"Simultaneous induction of rheumatoid factor and antigen\u2010specific antibody secreting cells during the secondary immune response in man","volume":"61","author":"Tarkowski A","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(86)90039-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1989.tb01199.x"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780340708","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780340708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:10:05Z","timestamp":1700759405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780340708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1002\/art.1780340708"],"URL":"https:\/\/doi.org\/10.1002\/art.1780340708","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}