{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:18:43Z","timestamp":1759479523234},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5275,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We quantified rheumatoid factor cross\u2010reactive idiotype (RF\u2010CRI) in whole serum from RF+ rheumatoid arthritis (RA) patients, using an inhibition enzymelinked immunosorbent assay which is not affected by the presence of IgG. Serum from 16 RF+ RA patients contained 2\u2013252 \u03bcg\/ml RF\u2010CRI (geometric mean *\/\u00f7 SD 20.8 *\/\u00f7 5.2), while serum from 11 normal adults contained 1\u201316 \u03bcg\/ml RF\u2010CRI (geometric mean *\/\u00f7 SD 3.9 *\/\u00f7 2.3). Serum from 8 of the RF+ RA patients contained RF\u2010CRI at concentrations more than 2 standard deviations above the geometric mean in the normal subjects (&gt;21 \u03bcg\/ml). Our results indicate that some RF+ RA patients express high concentrations of RF\u2010RCRI and immunoglobulin molecules that express the RF\u2010CRI may not be RF.<\/jats:p>","DOI":"10.1002\/art.1780340709","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T23:40:30Z","timestamp":1171496430000},"page":"840-845","source":"Crossref","is-referenced-by-count":6,"title":["Expression of large quantities of rheumatoid factor major cross\u2010reactive idiotype in the serum of adults with seropositive rheumatoid arthritis"],"prefix":"10.1002","volume":"34","author":[{"given":"Josiah F.","family":"Wedgwood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Hatam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent R.","family":"Bonagura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.2.331"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110575"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541277"},{"key":"e_1_2_1_5_2","volume-title":"Idiotype regulation and rheumatoid factors, Idiotypes","author":"Pernis B","year":"1986"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1979.tb02732.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320204"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.4049\/jimmunol.135.3.1955","article-title":"Structural similarities in the kappa light chains of human rheumatoid factor paraproteins and serum immunoglobulins bearing a cross\u2010reactive idiotype","volume":"135","author":"Fong S","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.1.122"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1986.tb01955.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.4049\/jimmunol.144.9.3468","article-title":"Dissociation of expression of two rheumatoid factor crossreactive kappa L chain idiotypes in rheumatoid arthritis","volume":"144","author":"Koopman WJ","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112888"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_1_14_2","first-page":"888","article-title":"The Latex fixation test. I. Application to the serologic diagnosis or rheumatoid arthritis","volume":"21","author":"Singer JM","year":"1956","journal-title":"Am J Med"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-68-16375"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1940.tb01475.x"},{"key":"e_1_2_1_17_2","first-page":"207","article-title":"The V\u2010kappaIIIb light chain sub\u2010subgroup: restricted association with mu heavy chain in normal human serum","volume":"54","author":"Moynihan JA","year":"1985","journal-title":"Immunology"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/ard.48.6.488","article-title":"Some adult patients with seronegative rheumatoid arthritis express the major rheumatoid cross\u2010reactive idiotype","volume":"48","author":"Bonagura VR","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_1_19_2","volume-title":"Ion exchange chromatography and gel filtration, Handbook of Experimental Immunology","author":"Fahey JL","year":"1978"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.108.1.139"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4049\/jimmunol.120.4.1395","article-title":"The subclass specificity for the binding of murine myeloma proteins to macrophages and lymphocyte cell lines and to normal spleen cells","volume":"120","author":"Segal DM","year":"1978","journal-title":"J Immunol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830188909061980"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320306"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.4049\/jimmunol.138.5.1391","article-title":"Rheumatoid factors from patients with rheumatoid arthritis possess private repertoires of idiotypes","volume":"138","author":"Nelson JL","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.5.1809"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.4049\/jimmunol.116.6.1532","article-title":"Blocking of certain antigenic sites in the F(ab) region by combination of univalent fragments of Rh antibodies with red cell antigens","volume":"116","author":"Kunkel HG","year":"1976","journal-title":"J Immunol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.6.1514"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.6.1334"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2333521"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.120.6.1215"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(84)90151-2"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(76)90347-5"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1978.tb00484.x"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.4049\/jimmunol.140.10.3411","article-title":"Incidence of three cross\u2010reactive idiotypes on human rheumatoid factor paraproteins","volume":"140","author":"Crowley JJ","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.136.2.477","article-title":"Expression of a cross\u2010reactive idiotype on rheumatoid factor in patients with Sjogren's syndrome","volume":"136","author":"Fox RI","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.10.2616"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780340709","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780340709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:10:11Z","timestamp":1700759411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780340709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1002\/art.1780340709"],"URL":"https:\/\/doi.org\/10.1002\/art.1780340709","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}